↓ Skip to main content

Dove Medical Press

Article Metrics

A meta-analysis of lipid peroxidation markers in major depression

Overview of attention for article published in Neuropsychiatric Disease and Treatment, September 2015
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
53 Mendeley
Title
A meta-analysis of lipid peroxidation markers in major depression
Published in
Neuropsychiatric Disease and Treatment, September 2015
DOI 10.2147/ndt.s89922
Pubmed ID
Authors

Krista L. Lanctot, Graham Mazereeuw, Nathan Herrmann, Ana Andreazza, Maisha Khan

Abstract

Major depressive disorder (MDD) may be associated with oxidative damage to lipids, which can potentially affect mood-regulating pathways. This meta-analysis summarizes current knowledge regarding lipid peroxidation markers in clinical samples of MDD and the effects of antidepressant pharmacotherapy on those markers. MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Collaboration were searched for original, peer-reviewed articles measuring markers of lipid peroxidation in patients with MDD and nondepressed healthy controls up to April 2015. Standardized mean differences (SMDs) were generated from random effects models summarizing mean (± standard deviations) concentrations of selected markers. Lipid peroxidation was greater in MDD than in controls (studies =17, N=857 MDD/782 control, SMD =0.83 [0.56-1.09], z=6.11, P<0.01, I (2)=84.0%) and was correlated with greater depressive symptom severity (B=0.05, df=8, P<0.01). Antidepressant treatment was associated with a reduction in lipid peroxidation in MDD patients (studies=5, N=222, SMD=0.71 [0.40-0.97], P<0.01; I (2)=42.5%). Lipid peroxidation markers were sampled from peripheral blood, included studies comparing MDD to controls were all cross-sectional, and only five antidepressant treatment studies were eligible for inclusion. Increased lipid peroxidation was associated with MDD and may be normalized by antidepressants. Continued investigation of lipid peroxidation in MDD is warranted.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Student > Doctoral Student 8 15%
Student > Ph. D. Student 7 13%
Student > Bachelor 5 9%
Student > Postgraduate 4 8%
Other 11 21%
Unknown 10 19%
Readers by discipline Count As %
Medicine and Dentistry 15 28%
Nursing and Health Professions 4 8%
Neuroscience 4 8%
Agricultural and Biological Sciences 4 8%
Psychology 4 8%
Other 7 13%
Unknown 15 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2015.
All research outputs
#8,185,596
of 14,535,828 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,079
of 2,442 outputs
Outputs of similar age
#106,555
of 249,818 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#61
of 96 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,818 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.