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Rapid and quantitative detection of C-reactive protein based on quantum dots and immunofiltration assay

Overview of attention for article published in International Journal of Nanomedicine, September 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

twitter
2 tweeters
googleplus
1 Google+ user

Citations

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11 Dimensions

Readers on

mendeley
46 Mendeley
Title
Rapid and quantitative detection of C-reactive protein based on quantum dots and immunofiltration assay
Published in
International Journal of Nanomedicine, September 2015
DOI 10.2147/ijn.s89307
Pubmed ID
Authors

Pengfei Zhang, Yan Bao, Mohamed Draz, Huiqi Lu, Chang Liu, Huanxing Han

Abstract

Convenient and rapid immunofiltration assays (IFAs) enable on-site "yes" or "no" determination of disease markers. However, traditional IFAs are commonly qualitative or semi-quantitative and are very limited for the efficient testing of samples in field diagnostics. Here, we overcome these limitations by developing a quantum dots (QDs)-based fluorescent IFA for the quantitative detection of C-reactive proteins (CRP). CRP, the well-known diagnostic marker for acute viral and bacterial infections, was used as a model analyte to demonstrate performance and sensitivity of our developed QDs-based IFA. QDs capped with both polyethylene glycol (PEG) and glutathione were used as fluorescent labels for our IFAs. The presence of the surface PEG layer, which reduced the non-specific protein interactions, in conjunction with the inherent optical properties of QDs, resulted in lower background signal, increased sensitivity, and ability to detect CRP down to 0.79 mg/L with only 5 µL serum sample. In addition, the developed assay is simple, fast and can quantitatively detect CRP with a detection limit up to 200 mg/L. Clinical test results of our QD-based IFA are well correlated with the traditional latex enhance immune-agglutination aggregation. The proposed QD-based fluorescent IFA is very promising, and potentially will be adopted for multiplexed immunoassay and in field point-of-care test.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Bachelor 7 15%
Student > Ph. D. Student 7 15%
Researcher 5 11%
Student > Postgraduate 3 7%
Other 7 15%
Unknown 8 17%
Readers by discipline Count As %
Medicine and Dentistry 8 17%
Chemistry 7 15%
Engineering 6 13%
Biochemistry, Genetics and Molecular Biology 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 6 13%
Unknown 13 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2015.
All research outputs
#2,357,644
of 6,420,515 outputs
Outputs from International Journal of Nanomedicine
#310
of 1,544 outputs
Outputs of similar age
#77,641
of 201,220 outputs
Outputs of similar age from International Journal of Nanomedicine
#35
of 144 outputs
Altmetric has tracked 6,420,515 research outputs across all sources so far. This one has received more attention than most of these and is in the 61st percentile.
So far Altmetric has tracked 1,544 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,220 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.