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Regulation of proteolytic cleavage of brain-derived neurotrophic factor precursor by antidepressants in human neuroblastoma cells

Overview of attention for article published in Neuropsychiatric Disease and Treatment, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

Mentioned by

twitter
3 tweeters
facebook
2 Facebook pages

Citations

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6 Dimensions

Readers on

mendeley
15 Mendeley
Title
Regulation of proteolytic cleavage of brain-derived neurotrophic factor precursor by antidepressants in human neuroblastoma cells
Published in
Neuropsychiatric Disease and Treatment, October 2015
DOI 10.2147/ndt.s87743
Pubmed ID
Authors

Pao-Yen Lin

Abstract

Evidence has supported the role of brain-derived neurotrophic factor (BDNF) in antidepressant effect. The precursor of BDNF (proBDNF) often exerts opposing biological effects on mature BDNF (mBDNF). Hence, the balance between proBDNF and mBDNF might be critical in total neurotrophic effects, leading to susceptibility to or recovery from depression. In the current study, we measured the protein expression levels of proBDNF, and its proteolytic products, truncated BDNF, and mBDNF, in human SH-SY5Y cells treated with different antidepressants. We found that the treatment significantly increased the production of mBDNF, but decreased the production of truncated BDNF and proBDNF. These results support that antidepressants can promote proBDNF cleavage. Further studies are needed to clarify whether proBDNF cleavage plays a role in antidepressant mechanisms.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 27%
Student > Ph. D. Student 4 27%
Student > Master 2 13%
Student > Postgraduate 1 7%
Lecturer 1 7%
Other 3 20%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 27%
Medicine and Dentistry 3 20%
Unspecified 2 13%
Psychology 2 13%
Neuroscience 2 13%
Other 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2015.
All research outputs
#7,064,385
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#956
of 2,120 outputs
Outputs of similar age
#104,047
of 247,710 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#65
of 96 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,710 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.