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Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy

Overview of attention for article published in International Journal of Nanomedicine, October 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

twitter
16 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
116 Dimensions

Readers on

mendeley
145 Mendeley
Title
Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy
Published in
International Journal of Nanomedicine, October 2015
DOI 10.2147/ijn.s92449
Pubmed ID
Authors

Sangiliyandi Gurunathan, Jae Woong Han, Jung-Hyun Park, Eun Su Kim, Yun-Jung Choi, Deug-Nam Kwon, Jin-Hoi Kim

Abstract

Graphene and graphene-based nanocomposites are used in various research areas including sensing, energy storage, and catalysis. The mechanical, thermal, electrical, and biological properties render graphene-based nanocomposites of metallic nanoparticles useful for several biomedical applications. Epithelial ovarian carcinoma is the fifth most deadly cancer in women; most tumors initially respond to chemotherapy, but eventually acquire chemoresistance. Consequently, the development of novel molecules for cancer therapy is essential. This study was designed to develop a simple, non-toxic, environmentally friendly method for the synthesis of reduced graphene oxide-silver (rGO-Ag) nanoparticle nanocomposites using Tilia amurensis plant extracts as reducing and stabilizing agents. The anticancer properties of rGO-Ag were evaluated in ovarian cancer cells. The synthesized rGO-Ag nanocomposite was characterized using various analytical techniques. The anticancer properties of the rGO-Ag nanocomposite were evaluated using a series of assays such as cell viability, lactate dehydrogenase leakage, reactive oxygen species generation, cellular levels of malonaldehyde and glutathione, caspase-3 activity, and DNA fragmentation in ovarian cancer cells (A2780). AgNPs with an average size of 20 nm were uniformly dispersed on graphene sheets. The data obtained from the biochemical assays indicate that the rGO-Ag nanocomposite significantly inhibited cell viability in A2780 ovarian cancer cells and increased lactate dehydrogenase leakage, reactive oxygen species generation, caspase-3 activity, and DNA fragmentation compared with other tested nanomaterials such as graphene oxide, rGO, and AgNPs. T. amurensis plant extract-mediated rGO-Ag nanocomposites could facilitate the large-scale production of graphene-based nanocomposites; rGO-Ag showed a significant inhibiting effect on cell viability compared to graphene oxide, rGO, and silver nanoparticles. The nanocomposites could be effective non-toxic therapeutic agents for the treatment of both cancer and cancer stem cells.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 <1%
Unknown 144 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 23%
Student > Master 31 21%
Student > Bachelor 13 9%
Researcher 10 7%
Student > Doctoral Student 8 6%
Other 23 16%
Unknown 26 18%
Readers by discipline Count As %
Chemistry 23 16%
Materials Science 21 14%
Engineering 15 10%
Biochemistry, Genetics and Molecular Biology 10 7%
Physics and Astronomy 9 6%
Other 31 21%
Unknown 36 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2019.
All research outputs
#1,413,129
of 15,520,561 outputs
Outputs from International Journal of Nanomedicine
#53
of 2,950 outputs
Outputs of similar age
#29,383
of 253,803 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 146 outputs
Altmetric has tracked 15,520,561 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,950 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,803 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.