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Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction

Overview of attention for article published in International Journal of Nanomedicine, October 2015
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Mentioned by

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3 tweeters

Citations

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13 Dimensions

Readers on

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15 Mendeley
Title
Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction
Published in
International Journal of Nanomedicine, October 2015
DOI 10.2147/ijn.s89783
Pubmed ID
Authors

Shinichi Asano, Ravikumar Arvapalli, Nandini Manne, Mani Maheshwari, Bing Ma, Kevin Rice, Vellaisamy Selvaraj, Eric Blough

Abstract

The severe inflammation observed during sepsis is thought to cause diaphragm dysfunction, which is associated with poor patient prognosis. Cerium oxide (CeO2) nanoparticles have been posited to exhibit anti-inflammatory and antioxidative activities suggesting that these particles may be of potential use for the treatment of inflammatory disorders. To investigate this possibility, Sprague Dawley rats were randomly assigned to the following groups: sham control, CeO2 nanoparticle treatment only (0.5 mg/kg iv), sepsis, and sepsis+CeO2 nanoparticles. Sepsis was induced by the introduction of cecal material (600 mg/kg) directly into the peritoneal cavity. Nanoparticle treatment decreased sepsis-associated impairments in diaphragmatic contractile (P o) function (sham: 25.6±1.6 N/cm(2) vs CeO2: 23.4±0.8 N/cm(2) vs Sep: 15.9±1.0 N/cm(2) vs Sep+CeO2: 20.0±1.0 N/cm(2), P<0.05). These improvements in diaphragm contractile function were accompanied by a normalization of protein translation signaling (Akt, FOXO-1, and 4EBP1), diminished proteolysis (caspase 8 and ubiquitin levels), and decreased inflammatory signaling (Stat3 and iNOS). Histological analysis suggested that nanoparticle treatment was associated with diminished sarcolemma damage and diminished inflammatory cell infiltration. These data indicate CeO2 nanoparticles may improve diaphragmatic function in the septic laboratory rat.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 13%
Other 2 13%
Professor 1 7%
Lecturer > Senior Lecturer 1 7%
Student > Doctoral Student 1 7%
Other 4 27%
Unknown 4 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 20%
Environmental Science 2 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Medicine and Dentistry 2 13%
Chemistry 1 7%
Other 0 0%
Unknown 5 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2015.
All research outputs
#2,790,538
of 6,346,128 outputs
Outputs from International Journal of Nanomedicine
#588
of 1,544 outputs
Outputs of similar age
#99,494
of 203,463 outputs
Outputs of similar age from International Journal of Nanomedicine
#88
of 145 outputs
Altmetric has tracked 6,346,128 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 1,544 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,463 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.