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Effects of silver nanoparticles on neonatal testis development in mice

Overview of attention for article published in International Journal of Nanomedicine, October 2015
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2 tweeters

Citations

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29 Dimensions

Readers on

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42 Mendeley
Title
Effects of silver nanoparticles on neonatal testis development in mice
Published in
International Journal of Nanomedicine, October 2015
DOI 10.2147/ijn.s90733
Pubmed ID
Authors

Sangiliyandi Gurunathan, Xi-Feng Zhang, Jin-Hoi Kim

Abstract

Metal nanoparticles (MNPs) play an important role in consumer products. An increasing use of MNPs has raised concerns about potential risks for human health. Therefore, in vivo tests of MNPs are urgently required. Using mice as a model animal, the aim of the present study was designed to investigate the effect of biologically synthesized silver nanoparticles (AgNPs) on spermatogenesis in neonatal mice. AgNPs were synthesized using Bacillus funiculus. The prepared nanoparticles were characterized using various analytical techniques such as UV-visible spectroscopy, X-ray diffraction, Fourier transform-infrared spectroscopy, and transmission electron microscopy. The prepared AgNPs were used to investigate testis development in neonatal mice. Institute of Cancer Research neonatal male mice were used in all experiments and were treated with different doses (0, 1, and 5 mg/kg) of AgNPs five times (interval of 3 days from postnatal day [PND] 8-21) by abdominal subcutaneous injection. The results showed that the sperm abnormalities such as quality and quantity were significantly increased by the synthesized AgNPs. The diameter of the convoluted tubules shrank significantly in mice treated with AgNPs on PND28 and PND42. The results of reverse transcription-quantitative polymerase chain reaction indicated that the E1f1ay, Gsta4, and Fdx1 genes were up-regulated, and the Amh, Cx43, and Claudin-11 genes were down-regulated in response to AgNPs exposure on PND28; however, these genes recovered at PND60. AgNPs had no effect on the recombination levels of chromosomes in germ cells. These results demonstrated the adverse effects of AgNPs on the male reproductive tract, particularly spermatogenesis and the quality of sperm. This study suggests that the development of nanomaterials should be safer and non-toxic to the living organisms and the potential reprotoxicity of AgNPs should be investigated more carefully.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 21%
Student > Bachelor 8 19%
Student > Ph. D. Student 5 12%
Student > Postgraduate 3 7%
Professor 3 7%
Other 7 17%
Unknown 7 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 33%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Nursing and Health Professions 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Immunology and Microbiology 2 5%
Other 9 21%
Unknown 10 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2015.
All research outputs
#5,490,603
of 9,728,122 outputs
Outputs from International Journal of Nanomedicine
#1,161
of 2,076 outputs
Outputs of similar age
#130,439
of 247,134 outputs
Outputs of similar age from International Journal of Nanomedicine
#113
of 147 outputs
Altmetric has tracked 9,728,122 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,076 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,134 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.