↓ Skip to main content

Dove Medical Press

Article Metrics

The expression and clinical significance of HDGF in osteosarcoma

Overview of attention for article published in OncoTargets and therapy, September 2015
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
3 Mendeley
Title
The expression and clinical significance of HDGF in osteosarcoma
Published in
OncoTargets and therapy, September 2015
DOI 10.2147/ott.s91708
Pubmed ID
Authors

Xiao-fei Lu, Zhiguo Chen, Shenghai Qiu

Abstract

To investigate the expression of hepatoma-derived growth factor (HDGF) in osteosarcoma (OS) and the correlation with clinicopathologic factors, prognosis, and tumor progression. HDGF expression in OS tissues was detected by immunohistochemistry. The correlation between HDGF and clinicopathologic factors was analyzed by chi-square test, and the association between HDGF expression and the overall survival rates was evaluated by univariate analysis using Kaplan-Meier method. HDGF concentration in cell medium or cell lysates was detected by enzyme-linked immunosorbent assay method. The effect of extrinsic and intrinsic HDGF on OS cell proliferation was detected by MTT assay after recombinant HDGF stimulation or HDGF knockdown, respectively. Proportion of HDGF high expression was 18.69% (20/107) in OS. HDGF high expression was significantly associated with larger tumor size (P=0.004). With experiments in vitro, we demonstrated that human recombinant HDGF could activate AKT and MAPK signaling pathway, resulting in OS cell proliferation. By knocking down HDGF expression, we proved that intrinsic HDGF was required in OS proliferation. High HDGF expression was significantly associated with larger OS tumor size and could promote OS cell proliferation, indicating that HDGF could be an effective biomarker and a potential drug target in OS treatment.

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Unknown 3 100%
Readers by discipline Count As %
Unknown 3 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2015.
All research outputs
#5,388,694
of 6,327,010 outputs
Outputs from OncoTargets and therapy
#442
of 746 outputs
Outputs of similar age
#160,622
of 202,134 outputs
Outputs of similar age from OncoTargets and therapy
#48
of 79 outputs
Altmetric has tracked 6,327,010 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 746 research outputs from this source. They receive a mean Attention Score of 1.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,134 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.