↓ Skip to main content

Dove Medical Press

Article Metrics

Escitalopram vs duloxetine in acute treatment of major depressive disorder: meta-analysis and systematic review

Overview of attention for article published in Neuropsychiatric Disease and Treatment, August 2018
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
22 Mendeley
Title
Escitalopram vs duloxetine in acute treatment of major depressive disorder: meta-analysis and systematic review
Published in
Neuropsychiatric Disease and Treatment, August 2018
DOI 10.2147/ndt.s152410
Pubmed ID
Authors

Benchalak Maneeton, Narong Maneeton, Surinporn Likhitsathian, Pakapan Woottiluk, Punjaree Wiriyacosol, Vudhichai Boonyanaruthee, Manit Srisurapanont

Abstract

Previous evidence indicated that efficacy of escitalopram (Esc) and duloxetine (Dul) was comparable in the treatment of major depressive disorder (MDD). Since such studies had small sample sizes, this study purposefully applied a systematic review to determine the efficacy, acceptability, and tolerability those antidepressants in treatment of MDD. The following primary databases were searched in July 2017: Scopus, PubMed, CINAHL, and Cochrane Controlled Trials Register. Any randomized controlled trials (RCTs) of Esc comparison with Dul in the treatment of MDD were included in this review. The primary efficacy of outcome was the pooled mean-changed scores of the rating scales for the standardized rating scales for depression. A total of 1,120 randomized subjects from 3 RCTs were collected for synthesis in the present meta-analysis. The mean-changed scores of the Hamilton Depression Rating Scale (HAMD) and Clinical Global Impression - Severity, overall response rate by the HAMD, and remission rate by the HAMD and Montgomery-Asberg Depression Rating Scale (MADRS) in the Esc- and Dul-treated groups showed no significant differences. However, the mean-changed score of the MARDS, mean-end scores of Clinical Global Impression - Improvement, and overall response by the MADRS in the Esc-treated group were greater than that of the Dul-treated group. Although the overall discontinuation rate had no significant differences between the 2 groups, the discontinuation rate due to adverse events in the Esc-treated group was greater than that of the Dul-treated group. This review had limited eligible studies. This review indicated the efficacy in the acute treatment of Esc vs Dul varied relying on measurements across the studies. However, the tolerability of Esc was superior to Dul in acute MDD treatment. Therefore, selection between the 2 antidepressants may depend on the tolerability of MDD patients. Due to limited included studies in this review, more large-scale and well-defined RCTs in such patients should be carried out to determine these outcomes.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 18%
Student > Master 3 14%
Other 3 14%
Student > Ph. D. Student 1 5%
Librarian 1 5%
Other 4 18%
Unknown 6 27%
Readers by discipline Count As %
Medicine and Dentistry 11 50%
Psychology 2 9%
Decision Sciences 1 5%
Social Sciences 1 5%
Arts and Humanities 1 5%
Other 1 5%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2018.
All research outputs
#12,950,475
of 14,687,926 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,964
of 2,442 outputs
Outputs of similar age
#235,798
of 274,707 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#49
of 76 outputs
Altmetric has tracked 14,687,926 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,707 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.