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Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Overview of attention for article published in International Journal of Nanomedicine, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
39 Mendeley
Title
Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation
Published in
International Journal of Nanomedicine, October 2015
DOI 10.2147/ijn.s87143
Pubmed ID
Authors

Dandan Liu, Hao Pan, Fengwei He, Xiaoyu Wang, Jinyu Li, Xinggang Yang, Weisan Pan

Abstract

The purpose of this work was to explore the particle size reduction effect of carvedilol on dissolution and absorption. Three suspensions containing different sized particles were prepared by antisolvent precipitation method or in combination with an ultrasonication process. The suspensions were characterized for particle size, surface morphology, and crystalline state. The crystalline form of carvedilol was changed into amorphous form after antisolvent precipitation. The dissolution rate of carvedilol was significantly accelerated by a reduction in particle size. The intestinal absorption of carvedilol nanosuspensions was greatly improved in comparison with microsuspensions and solution in the in situ single-pass perfusion experiment. The in vivo evaluation demonstrated that carvedilol nanosuspensions and microsuspensions exhibited markedly increased C max (2.09- and 1.48-fold) and AUC0- t (2.11- and 1.51-fold), and decreased T max (0.34- and 0.48-fold) in contrast with carvedilol coarse suspensions. Moreover, carvedilol nanosuspensions showed good biocompatibility with the rat gastric mucosa in in vivo gastrointestinal irritation test. The entire results implicated that the dissolution rate and the oral absorption of carvedilol were significantly affected by the particle size. Particle size reduction to form nanosized particles was found to be an efficient method for improving the oral bioavailability of carvedilol.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 23%
Student > Ph. D. Student 7 18%
Researcher 3 8%
Student > Doctoral Student 3 8%
Student > Bachelor 2 5%
Other 6 15%
Unknown 9 23%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 12 31%
Medicine and Dentistry 6 15%
Chemistry 4 10%
Biochemistry, Genetics and Molecular Biology 2 5%
Agricultural and Biological Sciences 1 3%
Other 1 3%
Unknown 13 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2015.
All research outputs
#2,555,963
of 6,241,002 outputs
Outputs from International Journal of Nanomedicine
#458
of 1,552 outputs
Outputs of similar age
#85,410
of 194,024 outputs
Outputs of similar age from International Journal of Nanomedicine
#62
of 135 outputs
Altmetric has tracked 6,241,002 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,552 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,024 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.