| Title |
Recent advances in "smart" delivery systems for extended drug release in cancer therapy
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2018
|
| DOI | 10.2147/ijn.s168053 |
| Pubmed ID | |
| Authors |
Regina-Veronicka Kalaydina, Komal Bajwa, Bessi Qorri, Alexandria Decarlo, Myron R Szewczuk |
| Abstract |
Advances in nanomedicine have become indispensable for targeted drug delivery, early detection, and increasingly personalized approaches to cancer treatment. Nanoparticle-based drug-delivery systems have overcome some of the limitations associated with traditional cancer-therapy administration, such as reduced drug solubility, chemoresistance, systemic toxicity, narrow therapeutic indices, and poor oral bioavailability. Advances in the field of nanomedicine include "smart" drug delivery, or multiple levels of targeting, and extended-release drug-delivery systems that provide additional methods of overcoming these limitations. More recently, the idea of combining smart drug delivery with extended-release has emerged in hopes of developing highly efficient nanoparticles with improved delivery, bioavailability, and safety profiles. Although functionalized and extended-release drug-delivery systems have been studied extensively, there remain gaps in the literature concerning their application in cancer treatment. We aim to provide an overview of smart and extended-release drug-delivery systems for the delivery of cancer therapies, as well as to introduce innovative advancements in nanoparticle design incorporating these principles. With the growing need for increasingly personalized medicine in cancer treatment, smart extended-release nanoparticles have the potential to enhance chemotherapy delivery, patient adherence, and treatment outcomes in cancer patients. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 25% |
| Sweden | 1 | 25% |
| United States | 1 | 25% |
| India | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 303 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 43 | 14% |
| Student > Ph. D. Student | 38 | 13% |
| Researcher | 33 | 11% |
| Student > Bachelor | 31 | 10% |
| Professor > Associate Professor | 9 | 3% |
| Other | 35 | 12% |
| Unknown | 114 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 36 | 12% |
| Chemistry | 30 | 10% |
| Biochemistry, Genetics and Molecular Biology | 28 | 9% |
| Engineering | 14 | 5% |
| Agricultural and Biological Sciences | 13 | 4% |
| Other | 47 | 16% |
| Unknown | 135 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2019.
All research outputs
#7,963,683
of 25,385,509 outputs
Outputs from International Journal of Nanomedicine
#941
of 4,122 outputs
Outputs of similar age
#126,908
of 341,886 outputs
Outputs of similar age from International Journal of Nanomedicine
#16
of 74 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.