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Study of association of PAX6 polymorphisms with susceptibility to high myopia in a Japanese population

Overview of attention for article published in Clinical Ophthalmology, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 tweeter
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1 Google+ user

Citations

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Readers on

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7 Mendeley
Title
Study of association of PAX6 polymorphisms with susceptibility to high myopia in a Japanese population
Published in
Clinical Ophthalmology, October 2015
DOI 10.2147/opth.s95167
Pubmed ID
Authors

Akira Meguro, Nobuyuki Kanemaki, Takahiro Yamane, Masaki Takeuchi, Eiichi Okada, Yasuhito Iijima, Nobuhisa Mizuki

Abstract

Many studies have investigated the relationship of paired box 6 (PAX6) gene polymorphisms with the risk of high myopia, but the results across studies remain inconsistent and ambiguous. In the present work, we investigated whether PAX6 polymorphisms are associated with high myopia in a Japanese population. A total of 1,585 Japanese patients with high myopia (spherical equivalent [SE] <-9.00 diopters [D]) and 1,011 Japanese healthy controls (SE≥-1.00 D) were recruited. To compare genotype frequencies between cases and controls, we genotyped five single nucleotide polymorphisms in the PAX6 gene that are reportedly associated with high/extreme myopia: rs662702, rs3026393, rs644242, rs3026390, and rs667773. For rs662702, rs644242, and rs667773, odds ratios (ORs) for their risk alleles tended to increase with the progression of SE and axial length in the additive and recessive models. Of these, rs644242 had the highest OR (2.56) in patients with SE<-15 D in both eyes in the recessive model. On the other hand, for rs3026393 and rs3026390, the ORs for their risk alleles tended to increase according to the progression of SE and axial length in the dominant model. Of the two, rs3026393 had the highest OR (2.32) in patients with SE<-15 D in both eyes in the dominant model. However, no significant associations were identified in this study. We found that these PAX6 single nucleotide polymorphisms were associated with an increased risk of extreme myopia. Although the results, which are in agreement with some previous studies, did not reach statistical significance, PAX6 single nucleotide polymorphisms may be important risk factors for the development of extreme myopia. Further genetic studies with larger sample sizes and taking into account the degree of myopia are needed to clarify the contribution of PAX6 variants in myopia development.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 14%
Unknown 6 86%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 1 14%
Student > Bachelor 1 14%
Student > Ph. D. Student 1 14%
Student > Master 1 14%
Researcher 1 14%
Other 0 0%
Unknown 2 29%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Agricultural and Biological Sciences 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%
Unknown 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2015.
All research outputs
#7,208,395
of 12,488,808 outputs
Outputs from Clinical Ophthalmology
#538
of 1,597 outputs
Outputs of similar age
#123,126
of 274,438 outputs
Outputs of similar age from Clinical Ophthalmology
#35
of 81 outputs
Altmetric has tracked 12,488,808 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,597 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.