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Aloe vera gel facilitates re-epithelialization of corneal alkali burn in normal and diabetic rats

Overview of attention for article published in Clinical Ophthalmology, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

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2 tweeters
googleplus
1 Google+ user

Citations

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20 Dimensions

Readers on

mendeley
43 Mendeley
Title
Aloe vera gel facilitates re-epithelialization of corneal alkali burn in normal and diabetic rats
Published in
Clinical Ophthalmology, October 2015
DOI 10.2147/opth.s90778
Pubmed ID
Authors

Tamer Wasfy, Ayman Atiba, Ahmed Ghoniem, Walied Abdo, Tarek Zayed, Mostafa Shokre

Abstract

To investigate the efficacy of topical applied aloe vera (AV) and to facilitate the repair of the standardized alkaline corneal ulcer in normal and diabetic rats. The corneal alkali-burn injury model was established unilaterally in Wistar rats by filter paper saturated with 0.01 M NaOH contacting the eyes for 45 seconds. Rats were divided into four groups: normal control (NC), normal AV (NAV), diabetic control (DC), and diabetic AV (DAV). NAV and DAV groups were treated with AV gel eye drops four times daily, and NC and DC groups were treated with normal saline for 3 days. Corneal epithelial wound closure and degree of edema were recorded using slit lamp and optical coherence tomography at 0, 24, 48, and 72 hours postwounding. Histological examination was conducted to evaluate the degree of inflammation and the healing effect. Corneal epithelial wound healing was better in the NAV group than in the NC group, and it was significantly higher in the DAV group than in the DC group (P<0.05). In comparison to the DC group, DAV treated with AV demonstrated a marked reduction in edema at 48 and 72 hours. Histologically, corneal re-epithelialization was complete and higher in DAV group than that in DC group; moreover, the inflammatory cells were increased in DC group than DAV group (P<0.05). This study demonstrated the efficacy of AV for enhanced corneal re-epithelialization, as well as reduced inflammatory response after alkali burn in rats; therefore, it could be useful as a therapy for diabetic keratopathy.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 19%
Student > Postgraduate 5 12%
Professor > Associate Professor 5 12%
Student > Doctoral Student 3 7%
Researcher 3 7%
Other 6 14%
Unknown 13 30%
Readers by discipline Count As %
Medicine and Dentistry 9 21%
Agricultural and Biological Sciences 6 14%
Veterinary Science and Veterinary Medicine 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Neuroscience 2 5%
Other 2 5%
Unknown 16 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2015.
All research outputs
#6,490,242
of 12,488,808 outputs
Outputs from Clinical Ophthalmology
#385
of 1,597 outputs
Outputs of similar age
#98,461
of 274,438 outputs
Outputs of similar age from Clinical Ophthalmology
#19
of 81 outputs
Altmetric has tracked 12,488,808 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,597 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.