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Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Overview of attention for article published in International Journal of Nanomedicine, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
66 Mendeley
Title
Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models
Published in
International Journal of Nanomedicine, October 2015
DOI 10.2147/ijn.s93918
Pubmed ID
Authors

Palanivel Ganesan, Hyun-Myung Ko, In-Su Kim, Dong-Kug Choi

Abstract

Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson's disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood-brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1-100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Bangladesh 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 15%
Student > Bachelor 10 15%
Student > Doctoral Student 10 15%
Student > Master 10 15%
Student > Ph. D. Student 9 14%
Other 17 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 20%
Unspecified 13 20%
Pharmacology, Toxicology and Pharmaceutical Science 11 17%
Biochemistry, Genetics and Molecular Biology 10 15%
Engineering 5 8%
Other 14 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2015.
All research outputs
#2,374,186
of 6,611,727 outputs
Outputs from International Journal of Nanomedicine
#255
of 1,615 outputs
Outputs of similar age
#77,357
of 208,632 outputs
Outputs of similar age from International Journal of Nanomedicine
#26
of 122 outputs
Altmetric has tracked 6,611,727 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 1,615 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.