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Memantine for the treatment of frontotemporal dementia: a meta-analysis

Overview of attention for article published in Neuropsychiatric Disease and Treatment, November 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

twitter
7 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
49 Mendeley
Title
Memantine for the treatment of frontotemporal dementia: a meta-analysis
Published in
Neuropsychiatric Disease and Treatment, November 2015
DOI 10.2147/ndt.s94430
Pubmed ID
Authors

Taro Kishi, Shinji Matsunaga, Nakao Iwata

Abstract

There is no conclusive evidence supporting the efficacy of memantine in frontotemporal dementia (FTD). We conducted a comprehensive meta-analysis of memantine concerning the efficacy and tolerability of memantine in FTD. Studies were identified through searches of PubMed, databases of the Cochrane Library, and PsycINFO citations up to April 10, 2015. Outcomes were Clinical Global Impression (primary), Mini-Mental State Examination, Neuropsychiatric Inventory, and Zarit Burden Interview scores as well as all-cause discontinuation. Standardized mean difference and risk ratio with 95% confidence interval were calculated. Two randomized controlled trials (RCTs) (total n=130) met the inclusion criteria. Memantine was marginally superior to placebo as assessed by the Clinical Global Impression scores (standardized mean difference =-0.34, 95% confidence interval =-0.68-0.01, P=0.06). However, there were no significant differences in Mini-Mental State Examination, Neuropsychiatric Inventory, and Zarit Burden Interview scores as well as all-cause discontinuation between memantine and placebo. Our results suggest that memantine may benefit FTD patients. However, because only two randomized controlled trials have addressed this issue, further studies using larger samples are needed.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Bachelor 7 14%
Student > Doctoral Student 7 14%
Student > Postgraduate 6 12%
Researcher 5 10%
Other 8 16%
Unknown 7 14%
Readers by discipline Count As %
Medicine and Dentistry 13 27%
Psychology 9 18%
Neuroscience 7 14%
Social Sciences 3 6%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 5 10%
Unknown 9 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2019.
All research outputs
#4,149,006
of 15,839,793 outputs
Outputs from Neuropsychiatric Disease and Treatment
#542
of 2,571 outputs
Outputs of similar age
#73,340
of 286,192 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#18
of 82 outputs
Altmetric has tracked 15,839,793 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,571 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,192 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.