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Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study

Overview of attention for article published in Neuropsychiatric Disease and Treatment, September 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

twitter
6 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

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10 Dimensions

Readers on

mendeley
41 Mendeley
Title
Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
Published in
Neuropsychiatric Disease and Treatment, September 2018
DOI 10.2147/ndt.s173280
Pubmed ID
Authors

Laisheng Cai, Jingwei Huang

Abstract

There is a need for biomarkers in multiple sclerosis (MS) to make an early diagnosis and monitor its progression. This study was designed to evaluate the value of neurofilament light (NFL) chain levels as cerebrospinal fluid (CSF) or blood biomarker in patients with MS by using a quantitative meta-analysis. The PubMed, Embase, and Web of Science databases were systematically searched for relevant studies. Articles in English that evaluated the utility of NFL in CSF and blood in the diagnosis of MS were included. Data were extracted by two independent researchers. Mean (± SD) NFL concentration for MS patients and control subjects were extracted. Review Manager version 5.3 software with a continuous-variable random-effects model was used to summarize the diagnostic indexes from eligible studies. The Newcastle-Ottawa Scale was used for assessing the quality and risk of bias of included studies. In addition, subgroup analysis and meta-regression were performed to assess potential heterogeneity sources. The meta-analysis included 13 articles containing results from 15 studies. A total of 10 studies measured NFL levels in CSF and five studies measured NFL levels in blood. Data were available on 795 participants in CSF and 1,856 participants in blood. Moreover, CSF NFL in MS patients was higher than that in healthy control groups (pooled standard mean difference [Std.MD]=0.88, 95% CI [0.50, 1.26], P<0.00001) and serum NFL in MS patients was higher than that in control subjects (pooled Std.MD=0.47, 95% CI [0.24, 0.71], P<0.0001). NFL chain has significantly increased in MS patients, which substantially strengthens the clinical evidence of the NFL in MS. The NFL may be used as a prognostic biomarker to monitor disease progression, disease activity, and treatment efficacy in the future.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Other 5 12%
Student > Master 4 10%
Researcher 4 10%
Student > Bachelor 3 7%
Other 6 15%
Unknown 9 22%
Readers by discipline Count As %
Medicine and Dentistry 18 44%
Neuroscience 6 15%
Biochemistry, Genetics and Molecular Biology 2 5%
Sports and Recreations 1 2%
Business, Management and Accounting 1 2%
Other 1 2%
Unknown 12 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2019.
All research outputs
#2,280,359
of 13,260,816 outputs
Outputs from Neuropsychiatric Disease and Treatment
#326
of 2,254 outputs
Outputs of similar age
#69,616
of 265,296 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#6
of 54 outputs
Altmetric has tracked 13,260,816 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,254 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,296 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.