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A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

Overview of attention for article published in International Journal of Nanomedicine, November 2015
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Mentioned by

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3 tweeters

Citations

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16 Dimensions

Readers on

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32 Mendeley
Title
A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil
Published in
International Journal of Nanomedicine, November 2015
DOI 10.2147/ijn.s89030
Pubmed ID
Authors

Thomas J Webster, Sima Singh, Niranjan Kotla, Sonia Tomar, Balaji Maddiboyina, Dinesh Sharma, Omprakash Sunnapu

Abstract

Targeted drug delivery plays a significant role in disease treatment associated with the colon, affording therapeutic responses for a prolonged period of time with low side effects. Colorectal cancer is the third most common cancer in both men and women with an estimated 102,480 cases of colon cancer and 40,340 cases of rectal cancer in 2013 as reported by the American Cancer Society. In the present investigation, we developed an improved oral delivery system for existing anticancer drugs meant for colon cancer via prebiotic and probiotic approaches. The system comprises three components, namely, nanoparticles of drug coated with natural materials such as guar gum, xanthan gum (that serve as prebiotics), and probiotics. The natural gums play a dual role of protecting the drug in the gastric as well as intestinal conditions to allow its release only in the colon. In vitro results obtained from these experiments indicated the successful targeted delivery of 5-fluorouracil to the colon. Electron microscopy results demonstrated that the prepared nanoparticles were spherical in shape and 200 nm in size. The in vitro release data indicated that the maximum release occurs at pH 7.2 and 7.4 with 93% of the drug released in the presence of 4% (w/v) of rat cecal content. In vivo results conclude a practical mechanism to maintain the integrity and intactness of the intestinal/colonic microflora, in the face of a "chemical attack" by oral colon-targeted drug delivery for colon cancer treatment.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 3%
United States 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 22%
Researcher 7 22%
Student > Ph. D. Student 4 13%
Student > Master 3 9%
Other 2 6%
Other 5 16%
Unknown 4 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 11 34%
Medicine and Dentistry 4 13%
Agricultural and Biological Sciences 3 9%
Neuroscience 2 6%
Psychology 1 3%
Other 5 16%
Unknown 6 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2015.
All research outputs
#2,940,310
of 6,602,221 outputs
Outputs from International Journal of Nanomedicine
#611
of 1,615 outputs
Outputs of similar age
#118,973
of 249,611 outputs
Outputs of similar age from International Journal of Nanomedicine
#62
of 94 outputs
Altmetric has tracked 6,602,221 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 1,615 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,611 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.