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A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

Overview of attention for article published in International Journal of Nanomedicine, November 2015
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Title
A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil
Published in
International Journal of Nanomedicine, November 2015
DOI 10.2147/ijn.s89030
Pubmed ID
Authors

Sima Singh, Niranjan G Kotla, Sonia Tomar, Balaji Maddiboyina, Thomas J Webster, Dinesh Sharma, Omprakash Sunnapu

Abstract

Targeted drug delivery plays a significant role in disease treatment associated with the colon, affording therapeutic responses for a prolonged period of time with low side effects. Colorectal cancer is the third most common cancer in both men and women with an estimated 102,480 cases of colon cancer and 40,340 cases of rectal cancer in 2013 as reported by the American Cancer Society. In the present investigation, we developed an improved oral delivery system for existing anticancer drugs meant for colon cancer via prebiotic and probiotic approaches. The system comprises three components, namely, nanoparticles of drug coated with natural materials such as guar gum, xanthan gum (that serve as prebiotics), and probiotics. The natural gums play a dual role of protecting the drug in the gastric as well as intestinal conditions to allow its release only in the colon. In vitro results obtained from these experiments indicated the successful targeted delivery of 5-fluorouracil to the colon. Electron microscopy results demonstrated that the prepared nanoparticles were spherical in shape and 200 nm in size. The in vitro release data indicated that the maximum release occurs at pH 7.2 and 7.4 with 93% of the drug released in the presence of 4% (w/v) of rat cecal content. In vivo results conclude a practical mechanism to maintain the integrity and intactness of the intestinal/colonic microflora, in the face of a "chemical attack" by oral colon-targeted drug delivery for colon cancer treatment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 1%
United States 1 1%
Unknown 83 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 15%
Student > Master 9 11%
Researcher 8 9%
Student > Ph. D. Student 8 9%
Other 4 5%
Other 11 13%
Unknown 32 38%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 19 22%
Biochemistry, Genetics and Molecular Biology 8 9%
Agricultural and Biological Sciences 7 8%
Medicine and Dentistry 4 5%
Immunology and Microbiology 2 2%
Other 10 12%
Unknown 35 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2015.
All research outputs
#16,720,137
of 25,371,288 outputs
Outputs from International Journal of Nanomedicine
#2,087
of 4,121 outputs
Outputs of similar age
#167,046
of 294,808 outputs
Outputs of similar age from International Journal of Nanomedicine
#70
of 112 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,121 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,808 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.