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Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects

Overview of attention for article published in International Journal of Nanomedicine, December 2015
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2 tweeters

Citations

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49 Mendeley
Title
Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects
Published in
International Journal of Nanomedicine, December 2015
DOI 10.2147/ijn.s88134
Pubmed ID
Authors

Mei-Ling Ho, Yin-Chih Fu, Yan-Hsiung Wang, Chung-Hwan Chen, Chih-Kuang Wang, Gwo-Jaw Wang

Abstract

Most allogenic bone graft substitutes have only osteoconductive properties. Developing new strategies to improve the osteoinductive activity of bone graft substitutes is both critical and practical for clinical application. Previously, we developed novel simvastatin-encapsulating poly(lactic-co-glycolic acid) microspheres (SIM/PLGA) that slowly release simvastatin and enhance fracture healing. In this study, we combined SIM/PLGA with a rapidly absorbable calcium sulfate (CS) bone substitute and studied the effect on bone healing in critical-sized calvarial bone defects in a rat model. The cytotoxicity and cytocompatibility of this combination was tested in vitro using lactate dehydrogenase leakage and a cell attachment assay, respectively. Combination treatment with SIM/PLGA and the CS bone substitute had no cytotoxic effect on bone marrow stem cells. Compared with the control, cell adhesion was substantially enhanced following combination treatment with SIM/PLGA and the CS bone substitute. In vivo, implantation of the combination bone substitute promoted healing of critical-sized calvarial bone defects in rats; furthermore, production of bone morphogenetic protein-2 and neovascularization were enhanced in the area of the defect. In summary, the combination of SIM/PLGA and a CS bone substitute has osteoconductive and osteoinductive properties, indicating that it could be used for regeneration of bone in the clinical setting.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
India 1 2%
Unknown 47 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 18%
Student > Master 7 14%
Other 4 8%
Researcher 4 8%
Student > Postgraduate 4 8%
Other 13 27%
Unknown 8 16%
Readers by discipline Count As %
Medicine and Dentistry 18 37%
Agricultural and Biological Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Chemistry 2 4%
Engineering 2 4%
Other 6 12%
Unknown 12 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2015.
All research outputs
#3,164,893
of 6,640,754 outputs
Outputs from International Journal of Nanomedicine
#924
of 1,615 outputs
Outputs of similar age
#133,220
of 253,670 outputs
Outputs of similar age from International Journal of Nanomedicine
#72
of 90 outputs
Altmetric has tracked 6,640,754 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,615 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,670 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.