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Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults

Overview of attention for article published in Neuropsychiatric Disease and Treatment, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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59 X users
facebook
2 Facebook pages
wikipedia
5 Wikipedia pages

Citations

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17 Dimensions

Readers on

mendeley
69 Mendeley
Title
Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults
Published in
Neuropsychiatric Disease and Treatment, September 2018
DOI 10.2147/ndt.s170645
Pubmed ID
Authors

Tia Sternat, Kathryn Fotinos, Alexa Fine, Irvin Epstein, Martin A Katzman

Abstract

The burdens imposed by treatment-resistant depression (TRD) necessitate the identification of predictive factors that may improve patient treatment and outcomes. Because depression and attention-deficit hyperactivity disorder (ADHD) are frequently comorbid and share a complex relationship, we hypothesized that ADHD may be a predictive factor for the diagnosis of TRD. This exploratory study aimed to determine the percentage of undetected ADHD in those with TRD and evaluate factors associated with treatment resistance and undetected ADHD in depressed patients. Adults referred (n=160) for psychiatric consultation completed a structured interview (MINI Plus, Mini International Neuropsychiatric Interview Plus) to assess the presence of psychiatric disorders. TRD was significantly associated with the number of diagnoses (P<0.001), past (P<0.001) and present medications (P<0.001), chronic anhedonia (P=0.013), and suicide ideation (P=0.008). Undetected ADHD was present in 34% of TRD patients. The number of referral diagnoses (P<0.001), failed medications (P=0.002), and past selective serotonin reuptake inhibitor failures (P=0.035) were predictive of undetected ADHD in TRD. Undetected ADHD may be more prevalent among TRD patients than previously thought. In addition, TRD patients are more likely to present with psychiatric comorbidity than non-TRD patients. Screening patients with depression for the presence of ADHD and chronic anhedonia/low hedonic tone may help identify patients with TRD and undetected ADHD and improve treatment outcomes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 16%
Student > Bachelor 8 12%
Student > Master 7 10%
Professor 4 6%
Student > Doctoral Student 3 4%
Other 12 17%
Unknown 24 35%
Readers by discipline Count As %
Psychology 20 29%
Medicine and Dentistry 6 9%
Neuroscience 5 7%
Business, Management and Accounting 2 3%
Nursing and Health Professions 2 3%
Other 8 12%
Unknown 26 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2024.
All research outputs
#914,579
of 25,519,924 outputs
Outputs from Neuropsychiatric Disease and Treatment
#114
of 3,140 outputs
Outputs of similar age
#19,393
of 346,131 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#1
of 101 outputs
Altmetric has tracked 25,519,924 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,140 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,131 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.