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Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults

Overview of attention for article published in Neuropsychiatric Disease and Treatment, September 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

twitter
8 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
34 Mendeley
Title
Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults
Published in
Neuropsychiatric Disease and Treatment, September 2018
DOI 10.2147/ndt.s170645
Pubmed ID
Authors

Tia Sternat, Kathryn Fotinos, Alexa Fine, Irvin Epstein, Martin Katzman

Abstract

The burdens imposed by treatment-resistant depression (TRD) necessitate the identification of predictive factors that may improve patient treatment and outcomes. Because depression and attention-deficit hyperactivity disorder (ADHD) are frequently comorbid and share a complex relationship, we hypothesized that ADHD may be a predictive factor for the diagnosis of TRD. This exploratory study aimed to determine the percentage of undetected ADHD in those with TRD and evaluate factors associated with treatment resistance and undetected ADHD in depressed patients. Adults referred (n=160) for psychiatric consultation completed a structured interview (MINI Plus, Mini International Neuropsychiatric Interview Plus) to assess the presence of psychiatric disorders. TRD was significantly associated with the number of diagnoses (P<0.001), past (P<0.001) and present medications (P<0.001), chronic anhedonia (P=0.013), and suicide ideation (P=0.008). Undetected ADHD was present in 34% of TRD patients. The number of referral diagnoses (P<0.001), failed medications (P=0.002), and past selective serotonin reuptake inhibitor failures (P=0.035) were predictive of undetected ADHD in TRD. Undetected ADHD may be more prevalent among TRD patients than previously thought. In addition, TRD patients are more likely to present with psychiatric comorbidity than non-TRD patients. Screening patients with depression for the presence of ADHD and chronic anhedonia/low hedonic tone may help identify patients with TRD and undetected ADHD and improve treatment outcomes.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 18%
Researcher 6 18%
Student > Bachelor 4 12%
Student > Postgraduate 3 9%
Student > Ph. D. Student 3 9%
Other 4 12%
Unknown 8 24%
Readers by discipline Count As %
Psychology 12 35%
Neuroscience 6 18%
Medicine and Dentistry 4 12%
Computer Science 1 3%
Nursing and Health Professions 1 3%
Other 0 0%
Unknown 10 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2019.
All research outputs
#3,915,056
of 16,810,341 outputs
Outputs from Neuropsychiatric Disease and Treatment
#514
of 2,628 outputs
Outputs of similar age
#78,678
of 281,012 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#9
of 46 outputs
Altmetric has tracked 16,810,341 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,628 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.