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A critical appraisal of the misoprostol removable, controlled-release vaginal delivery system of labor induction

Overview of attention for article published in International Journal of Women's Health, November 2015
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Citations

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16 Mendeley
Title
A critical appraisal of the misoprostol removable, controlled-release vaginal delivery system of labor induction
Published in
International Journal of Women's Health, November 2015
DOI 10.2147/ijwh.s62372
Pubmed ID
Authors

Philippe Deruelle, Charlotte Patte

Abstract

Induction of labor is a major issue in pregnancy management. Finding strategies to increase rate and decrease time to vaginal delivery is an important goal, but maternal or neonatal safety must remain the primary objective. Misoprostol is a synthetic analogue of prostaglandin used off label to ripen the cervix and induce labor. The misoprostol vaginal insert (MVI) was designed to allow a controlled-release delivery of misoprostol (from 50 to 200 μg) with a removal tape. The objective of this review was to make a critical appraisal of this device referring to the literature. A literature search was performed in the PubMed and Cochrane databases using the keywords "vaginal misoprostol insert". Several studies compared different doses of MVI (50, 100, 150, and 200 μg) with the 10 mg dinoprostone insert. The 100 μg MVI compared with the dinoprostone vaginal insert (DVI) showed similar efficacy and no significant differences in cesarean delivery rate. MVI 200 μg compared with DVI showed a reduced time to vaginal delivery and oxytocin need but had an increased risk of uterine hyperstimulation. The rate of hyperstimulation syndrome was two to three times more frequent with the 200 μg MVI than the 100 μg. Current data suggest that the 100 μg MVI would provide the best balance between efficacy and safety. Further studies should be performed to evaluate this dose, especially in high-risk situations needing induction of labor.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 19%
Student > Master 3 19%
Other 2 13%
Researcher 2 13%
Student > Ph. D. Student 2 13%
Other 3 19%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 9 56%
Pharmacology, Toxicology and Pharmaceutical Science 3 19%
Biochemistry, Genetics and Molecular Biology 1 6%
Agricultural and Biological Sciences 1 6%
Arts and Humanities 1 6%
Other 0 0%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#3,287,531
of 6,790,336 outputs
Outputs from International Journal of Women's Health
#179
of 335 outputs
Outputs of similar age
#143,360
of 282,753 outputs
Outputs of similar age from International Journal of Women's Health
#11
of 14 outputs
Altmetric has tracked 6,790,336 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 335 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,753 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.