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Investigation and optimization of formulation parameters on preparation of targeted anti-CD205 tailored PLGA nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
4 tweeters
patent
1 patent

Citations

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20 Dimensions

Readers on

mendeley
52 Mendeley
Title
Investigation and optimization of formulation parameters on preparation of targeted anti-CD205 tailored PLGA nanoparticles
Published in
International Journal of Nanomedicine, December 2015
DOI 10.2147/ijn.s90866
Pubmed ID
Authors

Azita Haddadi, Sheikh Tasnim Jahan

Abstract

The purpose of this study was to assess the effect of various formulation parameters on anti-CD205 antibody decorated poly(d, l-lactide co-glycolide) (PLGA) nanoparticles (NPs) in terms of their ability to target dendritic cells (DCs). In brief, emulsification solvent evaporation technique was adapted to design NP formulations using two different viscosity grades (low and high) of both ester and carboxylic acid terminated PLGA. Incorporation of ligand was achieved following physical adsorption or chemical conjugation processes. The physicochemical characterizations of formulations were executed to assess the effects of different solvents (chloroform and ethyl acetate), stabilizer percentage, polymer types, polymer viscosities, ligand-NP bonding types, cross-linkers, and cryoprotectants (sucrose and trehalose). Modification of any of these parameters shows significant improvement of physicochemical properties of NPs. Ethyl acetate was the solvent of choice for the formulations to ensure better emulsion formation. Infrared spectroscopy confirmed the presence of anti-CD205 antibody in the NP formulation. Finally, cytotoxicity assay confirmed the safety profile of the NPs for DCs. Thus, ligand modified structurally concealed PLGA NPs is a promising delivery tool for targeting DCs in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 25%
Researcher 10 19%
Student > Master 9 17%
Student > Doctoral Student 7 13%
Student > Bachelor 6 12%
Other 1 2%
Unknown 6 12%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 12 23%
Agricultural and Biological Sciences 7 13%
Chemistry 6 12%
Engineering 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Other 12 23%
Unknown 6 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2021.
All research outputs
#5,241,673
of 21,353,399 outputs
Outputs from International Journal of Nanomedicine
#478
of 3,568 outputs
Outputs of similar age
#92,463
of 402,764 outputs
Outputs of similar age from International Journal of Nanomedicine
#9
of 93 outputs
Altmetric has tracked 21,353,399 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,568 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 402,764 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.