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The effects of amine-modified single-walled carbon nanotubes on the mouse microbiota

Overview of attention for article published in International Journal of Nanomedicine, September 2018
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Title
The effects of amine-modified single-walled carbon nanotubes on the mouse microbiota
Published in
International Journal of Nanomedicine, September 2018
DOI 10.2147/ijn.s168554
Pubmed ID
Authors

J Justin Mulvey, Eric R Littmann, Lilan Ling, Michael R McDevitt, Eric G Pamer, David A Scheinberg

Abstract

Amine-modified carbon nanotubes are drug delivery platforms with great potential that have not yet been applied in human clinical trials. Although modified nanotube vectors have the ability to carry multiple effectors, targeting agents, and even wrapped RNA, reports on unmodified, insoluble carbon nanotubes have highlighted inflammation in organs, including the intestine, with disruption of its resident microbiota. Disruption of the microbiota may allow for colonization by pathogenic bacteria, such as Clostridoidies difficile, stimulate immunoinfiltrates into the lamina propria or alter the absorption of therapeutics. Most proposed nanotube drugs are soluble, modified structures that are administered parenterally, and the majority of these soluble macromolecules are renally excreted; however, some are released into the bile, gaining access to the gastrointestinal tract. Using environmentally isolated BALB/C mice in oral and intraperitoneal dosing models, high dose (3.80 or 4.25 mg/week), we administered amine-modified, soluble carbon nanotubes for 7 or 8 weeks. The general health and weight of the mice were monitored weekly, and upon killing, the diversity and content of their colonic, cecal, and ileal microbiota were assessed using shotgun 16S DNA sequencing. We show that while oral administration at suprapharmacological doses modestly altered the α- and β-diversity of the mouse microbiome, these changes did not result in observed changes in clinical end points. Intraperitoneally-dosed mice exhibited none of the toxicities assessed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Ph. D. Student 3 19%
Student > Bachelor 3 19%
Student > Master 2 13%
Other 1 6%
Other 0 0%
Unknown 3 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 19%
Medicine and Dentistry 3 19%
Chemistry 2 13%
Nursing and Health Professions 2 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 1 6%
Unknown 4 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2018.
All research outputs
#12,015,062
of 13,549,479 outputs
Outputs from International Journal of Nanomedicine
#2,317
of 2,626 outputs
Outputs of similar age
#228,465
of 264,979 outputs
Outputs of similar age from International Journal of Nanomedicine
#21
of 21 outputs
Altmetric has tracked 13,549,479 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,626 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.