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Downregulation of microRNA-132 by DNA hypermethylation is associated with cell invasion in colorectal cancer

Overview of attention for article published in OncoTargets and therapy, December 2015
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1 tweeter

Citations

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21 Mendeley
Title
Downregulation of microRNA-132 by DNA hypermethylation is associated with cell invasion in colorectal cancer
Published in
OncoTargets and therapy, December 2015
DOI 10.2147/ott.s91560
Pubmed ID
Authors

Zhiwei Wang, Jun Qin, Jing Ke, Feiran Wang, Youlang Zhou, Yasu Jiang, Junfei Xu

Abstract

microRNAs (miRNAs) are small, noncoding RNAs that are involved in many biological processes, and aberrant regulation of miRNAs is always associated with cancer progression and development. Abnormal expression of miRNA-132 (miR-132) has been found in some types of cancer, but the effects and potential mechanisms of miR-132 in colorectal cancer (CRC) have not been explored to date. In this study, quantitative real-time polymerase chain reaction was used to investigate the level of miR-132 in CRC tissues and their paired adjacent normal tissues. Bioinformatics analysis indicated that the mechanism underlying the tumor suppressor role of miR-132 in CRC cells may play a role in tumor suppression by targeting paxillin. Furthermore, methylation-specific polymerase chain reaction was performed to evaluate the methylation status of the miR-132 regulatory region. A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, was used to activate the expression of miR-132 in CRC cells in vitro. Downregulation of miR-132 may occur as a result of hypermethylation and implies a poor prognosis in CRC; therefore, triggering miR-132 reexpression by using DNA methyltransferase inhibitors may be a potential molecular therapeutic target for CRC.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 33%
Student > Master 6 29%
Student > Bachelor 3 14%
Unspecified 3 14%
Researcher 2 10%
Other 0 0%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 48%
Agricultural and Biological Sciences 5 24%
Unspecified 3 14%
Environmental Science 1 5%
Medicine and Dentistry 1 5%
Other 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#5,807,136
of 6,790,336 outputs
Outputs from OncoTargets and therapy
#488
of 807 outputs
Outputs of similar age
#235,731
of 291,130 outputs
Outputs of similar age from OncoTargets and therapy
#108
of 214 outputs
Altmetric has tracked 6,790,336 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 807 research outputs from this source. They receive a mean Attention Score of 1.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,130 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 214 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.