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The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats

Overview of attention for article published in Drug Design, Development and Therapy, December 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

twitter
2 tweeters
peer_reviews
1 peer review site
facebook
2 Facebook pages

Citations

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15 Dimensions

Readers on

mendeley
19 Mendeley
Title
The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats
Published in
Drug Design, Development and Therapy, December 2015
DOI 10.2147/dddt.s91247
Pubmed ID
Authors

Abdel Aziz Ibrahim, Mahmood Ameen Abdulla, Maryam Hajrezaie, Ammar Bader, Naiyer Shahzad, Saeed S Al-Ghamdi, Ahmad S. Gushash, Mohadeseh Hasanpourghadi

Abstract

Monolluma quadrangula (Forssk.) Plowes is used in Saudi traditional medicines to treat gastric ulcers. The hydroalcoholic extract of M. quadrangula (MHAE) was used in an in vivo model to investigate its gastroprotective effects against ethanol-induced acute gastric lesions in rats. Five groups of Sprague Dawley rats were used. The first group was treated with 10% Tween 20 as a control. The other four groups included rats treated with absolute ethanol (5 mL/kg) to induce an ulcer, rats treated with 20 mg/kg omeprazole as a reference drug, and rats treated with 150 or 300 mg/kg MHAE. One hour later, the rats were administered absolute ethanol (5 mL/kg) orally. Animals fed with MHAE exhibited a significantly increased pH, gastric wall mucus, and flattening of the gastric mucosa, as well as a decreased area of gastric mucosal damage. Histology confirmed the results; extensive destruction of the gastric mucosa was observed in the ulcer control group, and the lesions penetrated deep into the gastric mucosa with leukocyte infiltration of the submucosal layer and edema. However, gastric protection was observed in the rats pre-fed with plant extracts. Periodic acid-Schiff staining of the gastric wall revealed a remarkably intensive uptake of magenta color in the experimental rats pretreated with MHAE compared to the ulcer control group. Immunohistochemistry staining revealed an upregulation of the Hsp70 protein and a downregulation of the Bax protein in rats pretreated with MHAE compared with the control rats. Gastric homogenate showed significantly increased catalase and superoxide dismutase, and the level of malondialdehyde (MDA) was reduced in the rats pretreated with MHAE compared to the control group. In conclusion, MHAE exhibited a gastroprotective effect against ethanol-induced gastric mucosal injury in rats. The mechanism of this gastroprotection included an increase in pH and gastric wall mucus, an increase in endogenous enzymes, and a decrease in the level of MDA. Furthermore, protection was given through the upregulation of Hsp70 and the downregulation of Bax proteins.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Saudi Arabia 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 16%
Student > Bachelor 3 16%
Student > Doctoral Student 2 11%
Professor 1 5%
Other 1 5%
Other 4 21%
Unknown 5 26%
Readers by discipline Count As %
Medicine and Dentistry 3 16%
Agricultural and Biological Sciences 2 11%
Unspecified 1 5%
Nursing and Health Professions 1 5%
Computer Science 1 5%
Other 2 11%
Unknown 9 47%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2018.
All research outputs
#6,749,510
of 13,266,991 outputs
Outputs from Drug Design, Development and Therapy
#291
of 1,385 outputs
Outputs of similar age
#121,075
of 359,532 outputs
Outputs of similar age from Drug Design, Development and Therapy
#19
of 83 outputs
Altmetric has tracked 13,266,991 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,385 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,532 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.