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Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Overview of attention for article published in Drug Design, Development and Therapy, December 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
23 Mendeley
Title
Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer
Published in
Drug Design, Development and Therapy, December 2015
DOI 10.2147/dddt.s95843
Pubmed ID
Authors

Bing Hao, Song Gao, Jianfeng Li, Chen Jiang, Bo Hong

Abstract

A gene drug delivery system for glioma therapy based on transferrin (Tf)-modified polyamidoamine dendrimer (PAMAM) was prepared. Gene drug, tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL)-encoding plasmid open reading frame (pORF-hTRAIL, Trail), was condensed by Tf-modified PAMAM to form nanoparticles (NPs). PAMAM-PEG-Tf/DNA NPs showed higher cellular uptake, in vitro gene expression, and cytotoxicity than PAMAM-PEG/DNA NPs in C6 cells. The in vivo targeting efficacy of NPs was visualized by ex vivo fluorescence imaging. Tf-modified NPs showed obvious glioma-targeting trend. Plasmid encoding green fluorescence protein (GFP) was also condensed by modified or unmodified PAMAM to evaluate the in vivo gene expression level. The PAMAM-PEG-Tf/plasmid encoding enhanced green fluorescence protein (pEGFP) NPs exhibited higher GFP expression level than PAMAM-PEG/pEGFP NPs. TUNEL assay revealed that Tf-modified NPs could induce much more tumor apoptosis. The median survival time of PAMAM-PEG-Tf/Trail-treated rats (28.5 days) was longer than that of rats treated with PAMAM-PEG/Trail (25.5 days), temozolomide (24.5 days), PAMAM-PEG-Tf/pEGFP (19 days), or saline (17 days). The therapeutic effect was further confirmed by magnetic resonance imaging. This study demonstrated that targeting gene delivery system had potential application for the treatment of glioma.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 30%
Student > Bachelor 5 22%
Student > Doctoral Student 2 9%
Researcher 1 4%
Professor 1 4%
Other 3 13%
Unknown 4 17%
Readers by discipline Count As %
Medicine and Dentistry 3 13%
Neuroscience 3 13%
Agricultural and Biological Sciences 3 13%
Biochemistry, Genetics and Molecular Biology 3 13%
Chemistry 2 9%
Other 5 22%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2016.
All research outputs
#3,673,932
of 8,446,126 outputs
Outputs from Drug Design, Development and Therapy
#226
of 1,065 outputs
Outputs of similar age
#120,768
of 321,067 outputs
Outputs of similar age from Drug Design, Development and Therapy
#20
of 83 outputs
Altmetric has tracked 8,446,126 research outputs across all sources so far. This one has received more attention than most of these and is in the 55th percentile.
So far Altmetric has tracked 1,065 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,067 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.