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Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery

Overview of attention for article published in Drug Design, Development and Therapy, January 2016
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

twitter
3 tweeters

Citations

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30 Dimensions

Readers on

mendeley
41 Mendeley
Title
Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery
Published in
Drug Design, Development and Therapy, January 2016
DOI 10.2147/dddt.s91730
Pubmed ID
Authors

Heba Salem, Sayed M Ahmed, Mahmoud M Omar

Abstract

Nanoliposomes have an organized architecture that provides versatile functions. In this study, liposomes were used as an ocular carrier for nanogold capped with flucytosine antifungal drug. Gold nanoparticles were used as a contrasting agent that provides tracking of the drug to the posterior segment of the eye for treating fungal intraocular endophthalmitis. The nanoliposomes were prepared with varying molar ratios of lecithin, cholesterol, Span 60, a positive charge inducer (stearylamine), and a negative charge inducer (dicetyl phosphate). Formulation F6 (phosphatidylcholine, cholesterol, Span 60, and stearylamine at a molar ratio of 1:1:1:0.15) demonstrated the highest extent of drug released, which reached 7.043 mg/h. It had a zeta potential value of 42.5±2.12 mV and an average particle size approaching 135.1±12.0 nm. The ocular penetration of the selected nanoliposomes was evaluated in vivo using a computed tomography imaging technique. It was found that F6 had both the highest intraocular penetration depth (10.22±0.11 mm) as measured by the computed tomography and the highest antifungal efficacy when evaluated in vivo using 32 infected rabbits' eyes. The results showed a strong correlation between the average intraocular penetration of the nanoparticles capped with flucytosine and the percentage of the eyes healed. After 4 weeks, all the infected eyes (n=8) were significantly healed (P<0.01) when treated with liposomal formulation F6. Overall, the nanoliposomes encapsulating flucytosine have been proven efficient in treating the infected rabbits' eyes, which proves the efficiency of the nanoliposomes in delivering both the drug and the contrasting agent to the posterior segment of the eye.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 20%
Student > Ph. D. Student 5 12%
Student > Doctoral Student 4 10%
Professor > Associate Professor 4 10%
Lecturer 3 7%
Other 9 22%
Unknown 8 20%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 13 32%
Medicine and Dentistry 5 12%
Biochemistry, Genetics and Molecular Biology 3 7%
Immunology and Microbiology 2 5%
Chemistry 2 5%
Other 5 12%
Unknown 11 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2016.
All research outputs
#3,453,602
of 6,988,129 outputs
Outputs from Drug Design, Development and Therapy
#341
of 929 outputs
Outputs of similar age
#157,972
of 305,583 outputs
Outputs of similar age from Drug Design, Development and Therapy
#29
of 78 outputs
Altmetric has tracked 6,988,129 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 929 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,583 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.