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Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy

Overview of attention for article published in International Journal of Nanomedicine, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

blogs
1 blog
twitter
3 X users

Citations

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42 Dimensions

Readers on

mendeley
53 Mendeley
Title
Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy
Published in
International Journal of Nanomedicine, February 2016
DOI 10.2147/ijn.s94064
Pubmed ID
Authors

Bobe Petrushev, Sanda Boca, Timea Simon, Cristian Berce, Ioana Frinc, Delia Dima, Sonia Selicean, Grigore-Aristide Gafencu, Alina Tanase, Mihnea Zdrenghea, Adrian Florea, Sorina Suarasan, Liana Dima, Raluca Stanciu, Ancuta Jurj, Anca Buzoianu, Andrei Cucuianu, Simion Astilean, Alexandru Irimie, Ciprian Tomuleasa, Ioana Berindan-Neagoe

Abstract

Every year, in Europe, acute myeloid leukemia (AML) is diagnosed in thousands of adults. For most subtypes of AML, the backbone of treatment was introduced nearly 40 years ago as a combination of cytosine arabinoside with an anthracycline. This therapy is still the worldwide standard of care. Two-thirds of patients achieve complete remission, although most of them ultimately relapse. Since the FLT3 mutation is the most frequent, it serves as a key molecular target for tyrosine kinase inhibitors (TKIs) that inhibit FLT3 kinase. In this study, we report the conjugation of TKIs onto spherical gold nanoparticles. The internalization of TKI-nanocarriers was proved by the strongly scattered light from gold nanoparticles and was correlated with the results obtained by transmission electron microscopy and dark-field microscopy. The therapeutic effect of the newly designed drugs was investigated by several methods including cell counting assay as well as the MTT assay. We report the newly described bioconjugates to be superior when compared with the drug alone, with data confirmed by state-of-the-art analyses of internalization, cell biology, gene analysis for FLT3-IDT gene, and Western blotting to assess degradation of the FLT3 protein. The effective transmembrane delivery and increased efficacy validate its use as a potential therapeutic.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Romania 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 17%
Student > Master 9 17%
Student > Ph. D. Student 7 13%
Student > Postgraduate 4 8%
Researcher 4 8%
Other 6 11%
Unknown 14 26%
Readers by discipline Count As %
Medicine and Dentistry 14 26%
Biochemistry, Genetics and Molecular Biology 5 9%
Agricultural and Biological Sciences 3 6%
Nursing and Health Professions 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 7 13%
Unknown 20 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2016.
All research outputs
#3,247,994
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#173
of 4,123 outputs
Outputs of similar age
#54,214
of 406,420 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 86 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.