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Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy

Overview of attention for article published in International Journal of Nanomedicine, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#36 of 2,076)
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
44 Mendeley
Title
Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy
Published in
International Journal of Nanomedicine, February 2016
DOI 10.2147/ijn.s94064
Pubmed ID
Authors

Ciprian Tomuleasa, Bobe Petrushev, Sanda Boca, Timea Simon, Cristian Berce, Ioana Frinc, Delia Dima, Sonia Selicean, Grigore Aristide Gafencu, Alina Tanase, Mihnea Zdrenghea, Adrian Florea, Sorina Suarasan, Liana Dima, Raluca-Ana Stanciu, Ancuta-Maria Jurj, Anca Buzoianu, Andrei Cucuianu, Simion Astilean, Alexandru Irimie, Ioana Berindan-Neagoe

Abstract

Every year, in Europe, acute myeloid leukemia (AML) is diagnosed in thousands of adults. For most subtypes of AML, the backbone of treatment was introduced nearly 40 years ago as a combination of cytosine arabinoside with an anthracycline. This therapy is still the worldwide standard of care. Two-thirds of patients achieve complete remission, although most of them ultimately relapse. Since the FLT3 mutation is the most frequent, it serves as a key molecular target for tyrosine kinase inhibitors (TKIs) that inhibit FLT3 kinase. In this study, we report the conjugation of TKIs onto spherical gold nanoparticles. The internalization of TKI-nanocarriers was proved by the strongly scattered light from gold nanoparticles and was correlated with the results obtained by transmission electron microscopy and dark-field microscopy. The therapeutic effect of the newly designed drugs was investigated by several methods including cell counting assay as well as the MTT assay. We report the newly described bioconjugates to be superior when compared with the drug alone, with data confirmed by state-of-the-art analyses of internalization, cell biology, gene analysis for FLT3-IDT gene, and Western blotting to assess degradation of the FLT3 protein. The effective transmembrane delivery and increased efficacy validate its use as a potential therapeutic.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Romania 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Bachelor 7 16%
Student > Ph. D. Student 6 14%
Researcher 4 9%
Other 4 9%
Other 6 14%
Unknown 8 18%
Readers by discipline Count As %
Medicine and Dentistry 15 34%
Biochemistry, Genetics and Molecular Biology 4 9%
Agricultural and Biological Sciences 3 7%
Unspecified 2 5%
Nursing and Health Professions 2 5%
Other 7 16%
Unknown 11 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2016.
All research outputs
#981,163
of 9,728,122 outputs
Outputs from International Journal of Nanomedicine
#36
of 2,076 outputs
Outputs of similar age
#40,509
of 294,183 outputs
Outputs of similar age from International Journal of Nanomedicine
#2
of 90 outputs
Altmetric has tracked 9,728,122 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,076 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,183 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.