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Silent information regulator T1 in aqueous humor of patients with cataract

Overview of attention for article published in Clinical Ophthalmology, February 2016
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Citations

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Title
Silent information regulator T1 in aqueous humor of patients with cataract
Published in
Clinical Ophthalmology, February 2016
DOI 10.2147/opth.s100213
Pubmed ID
Authors

Aki Kondo, Mari Goto, Tatsuya Mimura, Masao Matsubara

Abstract

Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. This study was conducted at a university teaching hospital in Tokyo, Japan. This study was designed based on the consecutive case series. Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay. Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05). These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 29%
Other 2 29%
Student > Postgraduate 1 14%
Lecturer > Senior Lecturer 1 14%
Unknown 1 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 29%
Medicine and Dentistry 2 29%
Psychology 1 14%
Unknown 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#9,995,742
of 12,488,808 outputs
Outputs from Clinical Ophthalmology
#1,036
of 1,597 outputs
Outputs of similar age
#189,719
of 272,124 outputs
Outputs of similar age from Clinical Ophthalmology
#50
of 63 outputs
Altmetric has tracked 12,488,808 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,597 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,124 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.