| Title |
Silent information regulator T1 in aqueous humor of patients with cataract
|
|---|---|
| Published in |
Clinical Ophthalmology, February 2016
|
| DOI | 10.2147/opth.s100213 |
| Pubmed ID | |
| Authors |
Aki Kondo, Mari Goto, Tatsuya Mimura, Masao Matsubara |
| Abstract |
Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. This study was conducted at a university teaching hospital in Tokyo, Japan. This study was designed based on the consecutive case series. Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay. Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05). These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 29% |
| Other | 2 | 29% |
| Student > Postgraduate | 1 | 14% |
| Lecturer > Senior Lecturer | 1 | 14% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 29% |
| Medicine and Dentistry | 2 | 29% |
| Psychology | 1 | 14% |
| Unknown | 2 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Clinical Ophthalmology
#2,605
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Outputs of similar age
#300,610
of 406,412 outputs
Outputs of similar age from Clinical Ophthalmology
#48
of 61 outputs
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