| Title |
Fuchs endothelial corneal dystrophy: current perspectives
|
|---|---|
| Published in |
Clinical Ophthalmology, February 2016
|
| DOI | 10.2147/opth.s83467 |
| Pubmed ID | |
| Authors |
Gustavo Vedana, Guadalupe Villarreal, Albert S Jun |
| Abstract |
Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet's membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD's clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Unknown | 155 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 15% |
| Student > Ph. D. Student | 18 | 11% |
| Student > Bachelor | 17 | 11% |
| Other | 17 | 11% |
| Student > Master | 16 | 10% |
| Other | 31 | 20% |
| Unknown | 34 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 35% |
| Biochemistry, Genetics and Molecular Biology | 24 | 15% |
| Agricultural and Biological Sciences | 9 | 6% |
| Nursing and Health Professions | 7 | 4% |
| Unspecified | 6 | 4% |
| Other | 15 | 10% |
| Unknown | 41 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
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#20,655,488
of 25,371,288 outputs
Outputs from Clinical Ophthalmology
#2,605
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Outputs of similar age
#300,609
of 406,420 outputs
Outputs of similar age from Clinical Ophthalmology
#48
of 61 outputs
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