↓ Skip to main content

Dove Medical Press

Macrophage-mediated response to hypoxia in disease

Overview of attention for article published in Hypoxia, November 2014
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
52 Mendeley
Title
Macrophage-mediated response to hypoxia in disease
Published in
Hypoxia, November 2014
DOI 10.2147/hp.s49717
Pubmed ID
Authors

Craig Murdoch, Simon Tazzyman, Jack Harrison, James Yeomans, Munitta Muthana, Tazzyman, S., Murdoch, C., Yeomans, J., Harrison, J., Muthana, M., Tazzyman, Simon, Murdoch, Craig, Yeomans, James, Harrison, Jack, Muthana, Munitta

Abstract

Hypoxia plays a critical role in the pathobiology of various inflamed, diseased tissues, including malignant tumors, atherosclerotic plaques, myocardial infarcts, the synovia of rheumatoid arthritic joints, healing wounds, and sites of bacterial infection. These areas of hypoxia form when the blood supply is occluded and/or the oxygen supply is unable to keep pace with cell growth and/or infiltration of inflammatory cells. Macrophages are ubiquitous in all tissues of the body and exhibit great plasticity, allowing them to perform divergent functions, including, among others, patrolling tissue, combating invading pathogens and tumor cells, orchestrating wound healing, and restoring homeostasis after an inflammatory response. The number of tissue macrophages increases markedly with the onset and progression of many pathological states, with many macrophages accumulating in avascular and necrotic areas, where they are exposed to hypoxia. Recent studies show that these highly versatile cells then respond rapidly to the hypoxia present by altering their expression of a wide array of genes. Here we review the evidence for hypoxia-driven macrophage inflammatory responses in various disease states, and how this influences disease progression and treatment.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 1 2%
Unknown 51 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 17%
Student > Master 9 17%
Student > Bachelor 9 17%
Researcher 7 13%
Student > Doctoral Student 1 2%
Other 5 10%
Unknown 12 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 19%
Medicine and Dentistry 9 17%
Agricultural and Biological Sciences 8 15%
Immunology and Microbiology 6 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 6 12%
Unknown 11 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2016.
All research outputs
#18,445,779
of 22,854,458 outputs
Outputs from Hypoxia
#27
of 48 outputs
Outputs of similar age
#186,630
of 260,749 outputs
Outputs of similar age from Hypoxia
#1
of 1 outputs
Altmetric has tracked 22,854,458 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 48 research outputs from this source. They receive a mean Attention Score of 3.1. This one scored the same or higher as 21 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,749 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them