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Effects of copper oxide nanoparticles on developing zebrafish embryos and larvae

Overview of attention for article published in International Journal of Nanomedicine, March 2016
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37 Mendeley
Title
Effects of copper oxide nanoparticles on developing zebrafish embryos and larvae
Published in
International Journal of Nanomedicine, March 2016
DOI 10.2147/ijn.s100350
Pubmed ID
Authors

Yuhao Li, Yan Sun, Gong Zhang, Zizi He, Yajie Wang, Jianlin Cui

Abstract

Copper oxide nanoparticles (CuO NPs) are used for a variety of purposes in a wide range of commercially available products. Some CuO NPs probably end up in the aquatic systems, thus raising concerns about aqueous exposure toxicity, and the impact of CuO NPs on liver development and neuronal differentiation remains unclear. In this study, particles were characterized using Fourier transform infrared spectra, scanning electron microscopy, and transmission electron microscopy. Zebrafish embryos were continuously exposed to CuO NPs from 4 hours postfertilization at concentrations of 50, 25, 12.5, 6.25, or 1 mg/L. The expression of gstp1 and cyp1a was examined by quantitative reverse transcription polymerase chain reaction. The expression of tumor necrosis factor alpha and superoxide dismutase 1 was examined by quantitative reverse transcription polymerase chain reaction and Western blotting. Liver development and retinal neurodifferentiation were analyzed by whole-mount in situ hybridization, hematoxylin-eosin staining, and immunohistochemistry, and a behavioral test was performed to track the movement of larvae. We show that exposure of CuO NPs at low doses has little effect on embryonic development. However, exposure to CuO NPs at concentrations of 12.5 mg/L or higher leads to abnormal phenotypes and induces an inflammatory response in a dose-dependent pattern. Moreover, exposure to CuO NPs at high doses results in an underdeveloped liver and a delay in retinal neurodifferentiation accompanied by reduced locomotor ability. Our data demonstrate that short-term exposure to CuO NPs at high doses shows hepatotoxicity and neurotoxicity in zebrafish embryos and larvae.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
France 1 3%
Brazil 1 3%
Unknown 34 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 27%
Researcher 7 19%
Other 3 8%
Student > Master 3 8%
Student > Bachelor 3 8%
Other 7 19%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 22%
Environmental Science 6 16%
Biochemistry, Genetics and Molecular Biology 6 16%
Materials Science 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 11%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2016.
All research outputs
#5,571,421
of 7,367,723 outputs
Outputs from International Journal of Nanomedicine
#1,290
of 1,677 outputs
Outputs of similar age
#196,772
of 280,240 outputs
Outputs of similar age from International Journal of Nanomedicine
#84
of 92 outputs
Altmetric has tracked 7,367,723 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,677 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,240 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.