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Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

Overview of attention for article published in Drug Design, Development and Therapy, March 2016
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15 Mendeley
Title
Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids
Published in
Drug Design, Development and Therapy, March 2016
DOI 10.2147/dddt.s94710
Pubmed ID
Authors

Petra Czarniak, Michael Boddy, Bruce Sunderland, Jeff Hughes

Abstract

The purpose of this study was to evaluate the chemical stability of Lincocin(®) (lincomycin hydrochloride) in commonly used intravenous fluids at room temperature (25°C), at accelerated-degradation temperatures and in selected buffer solutions. The stability of Lincocin(®) injection (containing lincomycin 600 mg/2 mL as the hydrochloride) stored at 25°C±0.1°C in sodium lactate (Hartmann's), 0.9% sodium chloride, 5% glucose, and 10% glucose solutions was investigated over 31 days. Forced degradation of Lincocin(®) in hydrochloric acid, sodium hydroxide, and hydrogen peroxide was performed at 60°C. The effect of pH on the degradation rate of lincomycin hydrochloride stored at 80°C was determined. Lincomycin hydrochloride w as found to maintain its shelf life at 25°C in sodium lactate (Hartmann's) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution, with less than 5% lincomycin degradation occurring in all intravenous solutions over a 31-day period. Lincomycin hydrochloride showed less rapid degradation at 60°C in acid than in basic solution, but degraded rapidly in hydrogen peroxide. At all pH values tested, lincomycin followed first-order kinetics. It had the greatest stability near pH 4 when stored at 80°C (calculated shelf life of 4.59 days), and was least stable at pH 2 (calculated shelf life of 0.38 days). Lincocin(®) injection was chemically found to have a shelf life of at least 31 days at 25°C when added to sodium lactate (Hartmann's) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution. Solutions prepared at approximately pH 4 are likely to have optimum stability.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 13%
Student > Master 2 13%
Student > Ph. D. Student 2 13%
Professor 1 7%
Researcher 1 7%
Other 1 7%
Unknown 6 40%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 20%
Medicine and Dentistry 2 13%
Biochemistry, Genetics and Molecular Biology 2 13%
Agricultural and Biological Sciences 1 7%
Chemical Engineering 1 7%
Other 0 0%
Unknown 6 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#5,575,451
of 7,372,759 outputs
Outputs from Drug Design, Development and Therapy
#497
of 950 outputs
Outputs of similar age
#195,962
of 279,041 outputs
Outputs of similar age from Drug Design, Development and Therapy
#43
of 83 outputs
Altmetric has tracked 7,372,759 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 950 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,041 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.