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Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release

Overview of attention for article published in International Journal of Nanomedicine, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
5 tweeters
patent
1 patent

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
35 Mendeley
Title
Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
Published in
International Journal of Nanomedicine, March 2016
DOI 10.2147/ijn.s95375
Pubmed ID
Authors

Martin Andersson, Saba Atefyekta, Batur Ercan, Johan Karlsson, Erik Taylor, Stanley Chung, Thomas Webster

Abstract

Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa were used to evaluate their effectiveness toward inhibiting bacterial colonization. Drug loading and delivery were studied using a quartz crystal microbalance with dissipation monitoring, which showed successful loading and release of the antibiotics from the surfaces. Results from counting bacterial colony-forming units showed reduced bacterial adhesion on the drug-loaded films. Interestingly, the presence of the pores alone had a desired effect on bacterial colonization, which can be attributed to the documented nanotopographical effect. In summary, this study provides significant promise for the use of mesoporous titania thin films for reducing implant infections.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 43%
Student > Bachelor 6 17%
Student > Master 5 14%
Other 1 3%
Professor 1 3%
Other 3 9%
Unknown 4 11%
Readers by discipline Count As %
Materials Science 7 20%
Engineering 6 17%
Chemistry 6 17%
Agricultural and Biological Sciences 3 9%
Medicine and Dentistry 3 9%
Other 4 11%
Unknown 6 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2017.
All research outputs
#2,555,777
of 12,114,099 outputs
Outputs from International Journal of Nanomedicine
#191
of 2,387 outputs
Outputs of similar age
#68,303
of 287,093 outputs
Outputs of similar age from International Journal of Nanomedicine
#11
of 90 outputs
Altmetric has tracked 12,114,099 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,387 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.