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Microparticles in sputum of COPD patients: a potential biomarker of the disease?

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
6 tweeters
facebook
1 Facebook page

Citations

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21 Dimensions

Readers on

mendeley
43 Mendeley
Title
Microparticles in sputum of COPD patients: a potential biomarker of the disease?
Published in
International Journal of Chronic Obstructive Pulmonary Disease, March 2016
DOI 10.2147/copd.s99547
Pubmed ID
Authors

Chiara Porro, Donato Lacedonia, Giovanna Elisiana Carpagnano, Teresa Trotta, Grazia Palladino, Maria Antonietta Panaro, Luigi Zoppo, Maria Pia Foschino Barbaro

Abstract

Microparticles (MPs) are small membrane vesicles of 0.1-1 µm which are released by cells following chemical, physical, and apoptotic stimuli. MPs represent more than a miniature version of the cell. Their composition and function depend not only on cellular origin, but also on stimuli. Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by nearly irreversible lung destruction which results in airway limitation. We investigated the presence and source of MPs in sputum of COPD patients to evaluate if changes in MP number and origin may reflect the pathophysiological conditions of disease and may serve as potential biomarkers for diagnostic and prognostic use. Induced sputum samples were collected from 18 male subjects and liquefied with Sputasol. MPs obtained were immunolabeled for leukocyte (CD11a), granulocyte (CD66b), monocyte-macrophage (CD11b), platelets and megakaryocytic cells (CD41), endothelial cells (CD31), and red blood cells (CD235ab) and analyzed by cytofluorimetry. There was a negative correlation between CD31-MPs and forced expiratory volume in 1 second (R=-53, P<0.05) and CD66b-MP level was correlated with worse performance index of COPD such as the Body mass index airflow Obstruction, Dyspnea, and Exercise capacity (BODE); they were negatively correlated with 6-minute walking test: 0.65 and -0.64, respectively (P<0.05). CD235ab-MPs showed a negative correlation with body mass index (R=-0.86, P<0.05), while there was a positive correlation with dyspnea index (R=0.91, P<0.05). The main finding of this study was that MPs were detected in the sputum of patients affected by COPD. The phenotype of some of them was related to the main COPD parameters. These results suggest that MPs could be implicated in the pathogenesis of COPD.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 16%
Student > Ph. D. Student 6 14%
Student > Postgraduate 5 12%
Student > Master 5 12%
Other 4 9%
Other 12 28%
Unknown 4 9%
Readers by discipline Count As %
Medicine and Dentistry 12 28%
Biochemistry, Genetics and Molecular Biology 11 26%
Nursing and Health Professions 5 12%
Agricultural and Biological Sciences 3 7%
Environmental Science 2 5%
Other 3 7%
Unknown 7 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2016.
All research outputs
#1,610,024
of 7,506,617 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#228
of 939 outputs
Outputs of similar age
#77,616
of 276,437 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#30
of 71 outputs
Altmetric has tracked 7,506,617 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 939 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,437 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.