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Interleukin-18 and miR-130a in severe sepsis patients with thrombocytopenia

Overview of attention for article published in Patient preference and adherence, March 2016
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1 tweeter

Citations

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6 Mendeley
Title
Interleukin-18 and miR-130a in severe sepsis patients with thrombocytopenia
Published in
Patient preference and adherence, March 2016
DOI 10.2147/ppa.s95588
Pubmed ID
Authors

Yao-Li Cui, Yong-Qiang Wang, Bing Wang, Hong-Mei Gao, Ying-Hong Xing, Jian Li, Hong-Jie Li, Zhu Lin

Abstract

Thrombocytopenia is one of the most common laboratory abnormalities encountered in patients with severe sepsis. It has been reported that thrombocytopenia is linked to mortality in patients with severe sepsis. However, the mechanism of thrombocytopenia in sepsis is unknown. We hypothesized that inflammatory cytokines and microRNAs (miRNAs) are not only involved in the pathogenesis of sepsis, but also are correlated with thrombocytopenia. Eligible patients with severe sepsis were prospectively recruited and treated at our hospital between June 2012 and May 2014. The miRNA and protein expression of interleukin (IL)-18 and IL-27 were detected by real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The expression of miR-130a and miR-150 was detected by TaqMan real-time polymerase chain reaction. Sixty eligible patients were divided into two groups: 28 severe sepsis patients with thrombocytopenia and 32 severe sepsis patients without thrombocytopenia. The results demonstrated that the miRNA expression and plasma concentration of IL-18 in severe sepsis patients with thrombocytopenia were higher than those in severe sepsis patients without thrombocytopenia (P=0.015 and P=0.034, respectively), and miR-130a expression was significantly lower in severe sepsis patients with thrombocytopenia (P<0.003). Our data demonstrate that severe sepsis patients with thrombocytopenia have increased plasma and miRNA expression levels of IL-18 and decreased expression of miR-130a, suggesting that IL-18 and miR-130a might be involved in the pathophysiological process of severe sepsis with thrombocytopenia.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 33%
Student > Bachelor 1 17%
Student > Doctoral Student 1 17%
Student > Master 1 17%
Researcher 1 17%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 3 50%
Biochemistry, Genetics and Molecular Biology 2 33%
Immunology and Microbiology 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2016.
All research outputs
#6,496,358
of 7,499,955 outputs
Outputs from Patient preference and adherence
#672
of 740 outputs
Outputs of similar age
#229,836
of 271,809 outputs
Outputs of similar age from Patient preference and adherence
#64
of 64 outputs
Altmetric has tracked 7,499,955 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 740 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.