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Dual therapy strategies for COPD: the scientific rationale for LAMA + LABA

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, April 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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Citations

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83 Mendeley
Title
Dual therapy strategies for COPD: the scientific rationale for LAMA + LABA
Published in
International Journal of Chronic Obstructive Pulmonary Disease, April 2016
DOI 10.2147/copd.s54513
Pubmed ID
Authors

Joshua S Cohen, Matthew C Miles, James F Donohue, Jill A Ohar

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and health care expenditure worldwide. Relaxation of airway smooth muscle with inhaled bronchodilators is the cornerstone of treatment for stable COPD, with inhaled corticosteroids reserved for those with a history of exacerbations. Tiotropium has occupied center stage in COPD treatment for over 10 years and improves lung function, quality of life, exercise endurance, and reduces the risk of COPD exacerbation. Long-acting β2-agonists (LABAs) improve lung function, reduce dynamic hyperinflation, increase exercise tolerance, health-related quality of life, and reduce acute exacerbation of COPD. The combination of long-acting muscarinic antagonists (LAMAs) and LABAs is thought to leverage different pathways to induce bronchodilation using submaximal drug doses, increasing the benefits and minimizing receptor-specific side effects. Umeclidinium/vilanterol is the first combination of LAMA/LABA to be approved for use in stable COPD in USA and Europe. Additionally, indacaterol/glycopyrronium and aclidinium/formoterol have been approved in Europe and in numerous locations outside USA. Several other agents are in the late stages of development, most of which offer once-daily dosing. The benefits of new LAMA/LABA combinations include improved pulmonary function, dyspnea, and health-related quality of life, and in some cases, reduced exacerbations. These evolving treatments will provide new opportunities and challenges in the management of COPD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 83 100%

Demographic breakdown

Readers by professional status Count As %
Other 16 19%
Student > Bachelor 9 11%
Student > Ph. D. Student 8 10%
Researcher 8 10%
Student > Master 8 10%
Other 16 19%
Unknown 18 22%
Readers by discipline Count As %
Medicine and Dentistry 42 51%
Pharmacology, Toxicology and Pharmaceutical Science 8 10%
Biochemistry, Genetics and Molecular Biology 4 5%
Nursing and Health Professions 4 5%
Mathematics 1 1%
Other 2 2%
Unknown 22 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2016.
All research outputs
#14,256,694
of 25,374,917 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,171
of 2,577 outputs
Outputs of similar age
#144,634
of 314,727 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#37
of 68 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,727 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.