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Conjugation of insulin onto the sidewalls of single-walled carbon nanotubes through functionalization and diimide-activated amidation

Overview of attention for article published in International Journal of Nanomedicine, April 2016
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Mentioned by

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2 tweeters

Citations

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7 Dimensions

Readers on

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17 Mendeley
Title
Conjugation of insulin onto the sidewalls of single-walled carbon nanotubes through functionalization and diimide-activated amidation
Published in
International Journal of Nanomedicine, April 2016
DOI 10.2147/ijn.s98726
Pubmed ID
Authors

Sivakumar Manickam, Chee Meng Ng, Hwei-San Loh, Kasturi Muthoosamy, Nanthini Sridewi

Abstract

The high aspect ratio of carbon nanotubes (CNTs) allows the attachment of compounds that enhance the functionality of the drug vehicle. Considering this, use of CNTs as a multifunctional insulin carrier may be an interesting prospect to explore. The carboxylic acid groups were functionalized on the sidewalls of single-walled CNTs (SWCNTs) followed by diimidation to form amide bonds with the amine groups of the insulin. Scanning transmission electron microscopy and transmission electron microscopy establish clear conjugation of insulin onto the surface of nanotube sidewalls. The incorporation of insulin further increased the solubility of SWCNTs in biological solution for the tested period of 5 months. Bicinchoninic acid assay confirms that 0.42 mg of insulin could be attached to every 1 mg of carboxylated SWCNTs. With the successful conjugation of insulin to SWCNTs, it opens up the potential use of SWCNTs as an insulin carrier which in need of further biological studies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 29%
Student > Ph. D. Student 3 18%
Student > Master 3 18%
Unspecified 2 12%
Other 1 6%
Other 3 18%
Readers by discipline Count As %
Unspecified 3 18%
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Chemistry 3 18%
Chemical Engineering 2 12%
Engineering 2 12%
Other 4 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2016.
All research outputs
#3,912,323
of 7,571,218 outputs
Outputs from International Journal of Nanomedicine
#974
of 1,713 outputs
Outputs of similar age
#145,237
of 267,997 outputs
Outputs of similar age from International Journal of Nanomedicine
#91
of 124 outputs
Altmetric has tracked 7,571,218 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,713 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,997 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.