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Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment

Overview of attention for article published in Neuropsychiatric Disease and Treatment, April 2016
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Mentioned by

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3 tweeters
facebook
1 Facebook page

Citations

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4 Dimensions

Readers on

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6 Mendeley
Title
Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
Published in
Neuropsychiatric Disease and Treatment, April 2016
DOI 10.2147/ndt.s103336
Pubmed ID
Authors

Mehmet Ugur Cevik, Nilüfer Dönmezdil, Hasan H. Ozdemir, Muhterem Taşin

Abstract

There are many studies dedicated to researching the etiopathogenesis of epilepsy. In such research, oxidative and antioxidant indicators of etiopathogenesis have also been examined under the scope. Drawing on a group of patients with epilepsy who were receiving no treatment, we have tried to evaluate whether or not an increase in oxidative indicators is linked directly with the disorder, independent of epileptic medicaments. Thirty people in good health and 30 newly diagnosed with epilepsy and who received ambulatory treatment in the polyclinic of the Neurology Department took part in the study. The tests relating to serum malondialdehyde (MDA) levels and paraoxonase 1 (PON1) activity were carried out in the biochemistry laboratory. Even though the levels of MDA in the patient group (14.34±3.59 nmol/mL) were found to be high compared to those of the control group, which consisted of people in good health (13.53±3.56 nmol/mL), there was no statistically significant difference. PON1 activity in the serum taken from people in the patient group (0.65±0.17) was lower in comparison to that observed in the serum of the control group (0.71±0.17 U/L). Nonetheless, it was not so low as to have significance from a statistical point of view. We conclude that such a high level of oxidative parameters should have been related to the disease and that statistically significant findings that emerged in some other studies could have been related to an antiepileptic treatment.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 33%
Researcher 2 33%
Student > Ph. D. Student 1 17%
Other 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Biochemistry, Genetics and Molecular Biology 1 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 17%
Unknown 2 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2016.
All research outputs
#7,224,512
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,048
of 2,120 outputs
Outputs of similar age
#122,219
of 263,273 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#58
of 89 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.