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Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome

Overview of attention for article published in Clinical Ophthalmology, April 2016
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Title
Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
Published in
Clinical Ophthalmology, April 2016
DOI 10.2147/opth.s92174
Pubmed ID
Authors

Marios Giannakopoulos, Anna Antonacopoulou, Anastasia Kottorou, Haralabos Kalofonos, Sotirios Gartaganis

Abstract

In this study we aimed to evaluate the polymorphism at codon 129 (M129V) of the PRNP gene as a secondary risk factor for pseudoexfoliation syndrome (PEX). Two hundred and seventy-five unrelated subjects, including 156 patients with PEX and 119 unrelated control subjects, were recruited from the University Hospital of Patras, Greece. All patients and controls were of Caucasian or European ancestry. The PRNP M129V (A/G) single-nucleotide polymorphism was genotyped by real-time polymerase chain reactions. Association of the polymorphism with PEX was assessed using the two-sided Pearson's chi-squared or Fisher's exact test. No significant difference between patients and controls was observed in terms of frequencies of alleles and genotypes of the PRNP gene. Polymorphism at M129V of the PRNP gene was evaluated as a secondary risk factor for developing PEX. Our results suggest that this PRNP gene polymorphism is not associated with PEX.

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Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 50%
Unknown 1 50%
Readers by discipline Count As %
Unspecified 1 50%
Unknown 1 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2016.
All research outputs
#9,995,751
of 12,488,808 outputs
Outputs from Clinical Ophthalmology
#1,036
of 1,597 outputs
Outputs of similar age
#184,253
of 264,245 outputs
Outputs of similar age from Clinical Ophthalmology
#59
of 81 outputs
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We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.