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Transportan in nanocarriers improves skin localization and antitumor activity of paclitaxel

Overview of attention for article published in International Journal of Nanomedicine, May 2016
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Mentioned by

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3 tweeters

Citations

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16 Dimensions

Readers on

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29 Mendeley
Title
Transportan in nanocarriers improves skin localization and antitumor activity of paclitaxel
Published in
International Journal of Nanomedicine, May 2016
DOI 10.2147/ijn.s97331
Pubmed ID
Authors

Luciana Lopes, Dominique Pepe, Vanessa Carvalho, Melissa McCall, Débora de Lemos

Abstract

In this study, the ability of nanocarriers containing protein transduction domains (PTDs) of various classes to improve cutaneous paclitaxel delivery and efficacy in skin tumor models was evaluated. Microemulsions (MEs) were prepared by mixing a surfactant blend (polyoxyethylene 10 oleoyl ether, ethanol and propylene glycol), monocaprylin, and water. The PTD transportan (ME-T), penetratin (ME-P), or TAT (ME-TAT) was added at a concentration of 1 mM to the plain ME. All MEs displayed nanometric size (32.3-40.7 nm) and slight positive zeta potential (+4.1 mV to +6.8 mV). Skin penetration of paclitaxel from the MEs was assessed for 1-12 hours using porcine skin and Franz diffusion cells. Among the PTD-containing formulations, paclitaxel skin (stratum corneum + epidermis and dermis) penetration at 12 hours was maximized with ME-T, whereas ME-TAT provided the lowest penetration (1.6-fold less). This is consistent with the stronger ability of ME-T to increase transepidermal water loss (2.4-fold compared to water) and tissue permeability. The influence of PTD addition on the ME irritation potential was assessed by measuring interleukin-1α expression and viability of bioengineered skin equivalents. A 1.5- to 1.8-fold increase in interleukin-1α expression was induced by ME-T compared to the other formulations, but this effect was less pronounced (5.8-fold) than that mediated by the moderate irritant Triton. Because ME-T maximized paclitaxel cutaneous localization while being safer than Triton, its efficacy was assessed against basal cell carcinoma cells and a bioengineered three-dimensional melanoma model. Paclitaxel-containing ME-T reduced cells and tissue viability by twofold compared to drug solutions, suggesting the potential clinical usefulness of the formulation for the treatment of cutaneous tumors.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 17%
Student > Postgraduate 4 14%
Student > Master 4 14%
Student > Doctoral Student 3 10%
Researcher 3 10%
Other 4 14%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 5 17%
Agricultural and Biological Sciences 4 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Chemistry 2 7%
Chemical Engineering 1 3%
Other 4 14%
Unknown 10 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2016.
All research outputs
#3,759,683
of 7,690,167 outputs
Outputs from International Journal of Nanomedicine
#669
of 1,736 outputs
Outputs of similar age
#133,920
of 268,158 outputs
Outputs of similar age from International Journal of Nanomedicine
#65
of 128 outputs
Altmetric has tracked 7,690,167 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,736 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,158 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 128 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.