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Genes associated with Alzheimer's disease: an overview and current status

Overview of attention for article published in Clinical Interventions in Aging, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
twitter
12 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user
video
1 video uploader

Citations

dimensions_citation
81 Dimensions

Readers on

mendeley
245 Mendeley
Title
Genes associated with Alzheimer's disease: an overview and current status
Published in
Clinical Interventions in Aging, May 2016
DOI 10.2147/cia.s105769
Pubmed ID
Authors

Mohan Giri, Yang Lü, Man Zhang

Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-ε4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
United States 1 <1%
Unknown 243 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 50 20%
Student > Ph. D. Student 47 19%
Student > Bachelor 43 18%
Researcher 34 14%
Unspecified 23 9%
Other 48 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 63 26%
Neuroscience 41 17%
Agricultural and Biological Sciences 39 16%
Unspecified 35 14%
Medicine and Dentistry 25 10%
Other 42 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2019.
All research outputs
#869,896
of 13,444,886 outputs
Outputs from Clinical Interventions in Aging
#103
of 1,372 outputs
Outputs of similar age
#25,012
of 264,914 outputs
Outputs of similar age from Clinical Interventions in Aging
#3
of 56 outputs
Altmetric has tracked 13,444,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,372 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,914 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.