| Title |
Ultrasonic Nanoemulsification of Cuminum cyminum Essential Oil and Its Applications in Medicine
|
|---|---|
| Published in |
International Journal of Nanomedicine, February 2020
|
| DOI | 10.2147/ijn.s230893 |
| Pubmed ID | |
| Authors |
M Joyce Nirmala, Latha Durai, Kagitala Anvesh Rao, R Nagarajan |
| Abstract |
Cumin seed oil (extracted from Cuminum cyminum) has many applications but conclusive evidence of its therapeutic uses has not been presented. This study has explored the anticancer and antibacterial properties of the seed oil. The cumin nanoemulsion was prepared with Tween 80 non-ionic surfactant employing ultra-sonication technology. The anticancer activity of the nanoscale-based emulsion was evaluated through cell viability (MTT), antiproliferation evaluation through clonogenic assay, and apoptosis through Annexin V-FITC assay. Agar well diffusion was used to study the antimicrobial activity, and this was supported by membrane integrity analysis. A thorough study of process parameters, aimed at obtaining the optimal surface concentration and emulsification time, was completed. GC-MS data indicated cumaldehyde as a major component. The resultant droplet diameter after a sonication time of 5 min was 10.4 ± 0.5 nm. MTT assay revealed the IC50 value at 1.5 µL/mL and the early induction of apoptosis was evident. Tongue carcinoma cell line treated with cumin nanoemulsion presented a diminished colony formation. The nanoemulsion exhibited significant antibacterial activity against S. aureus. A significant cytoplasmic leakage was observed on treatment with cumin nanoemulsion. The consequences of the analysis projected cumin as a potential component for cancer therapy. This study provides definitive evidence for cumin essential oil nanoemulsion as a legitimate plant-based medicine that can bypass the drawbacks of the present aggressive treatment of cancer, can overcome the antimicrobial resistance, and can also meet all prerequisites. |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 92 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 11% |
| Student > Master | 8 | 9% |
| Student > Postgraduate | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Student > Ph. D. Student | 6 | 7% |
| Other | 12 | 13% |
| Unknown | 43 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 9% |
| Medicine and Dentistry | 6 | 7% |
| Chemistry | 6 | 7% |
| Veterinary Science and Veterinary Medicine | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 48 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2020.
All research outputs
#20,667,544
of 25,387,668 outputs
Outputs from International Journal of Nanomedicine
#3,129
of 4,123 outputs
Outputs of similar age
#353,754
of 470,256 outputs
Outputs of similar age from International Journal of Nanomedicine
#42
of 71 outputs
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So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.