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Acute and subchronic dermal toxicity of nanosilver in guinea pig

Overview of attention for article published in International Journal of Nanomedicine, April 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

policy
1 policy source
twitter
1 tweeter

Citations

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65 Dimensions

Readers on

mendeley
74 Mendeley
Title
Acute and subchronic dermal toxicity of nanosilver in guinea pig
Published in
International Journal of Nanomedicine, April 2011
DOI 10.2147/ijn.s17065
Pubmed ID
Authors

Mitra Korani, M Rezayat, K Gilani

Abstract

Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this study, we analyzed the potential toxicity of colloidal nanosilver in acute and subchronic guinea pigs. Before toxicity assessments, the size of colloidal nanosilver was recorded in sizes <100 nm by X-ray diffraction and transmission electron microscopy. For toxicological assessments, male guinea pigs weighing 350 to 400 g were exposed to two different concentrations of nanosilver (1000 and 10,000 μg/mL) in an acute study and three concentrations of nanosilver (100, 1000, and 10,000 μg/mL) in a subchronic study. Toxic responses were assessed by clinical and histopathologic parameters. In all experimental animals the sites of exposure were scored for any type of dermal toxicity and compared with negative control and positive control groups. In autopsy studies during the acute test, no significant changes in organ weight or major macroscopic changes were detected, but dose-dependent histopathologic abnormalities were seen in skin, liver, and spleen of all test groups. In addition, experimental animals subjected to subchronic tests showed greater tissue abnormalities than the subjects of acute tests. It seems that colloidal nanosilver has the potential to provide target organ toxicities in a dose- and time-dependent manner.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Poland 1 1%
Unknown 72 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 20%
Researcher 14 19%
Student > Doctoral Student 6 8%
Other 6 8%
Professor > Associate Professor 5 7%
Other 20 27%
Unknown 8 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 19%
Medicine and Dentistry 9 12%
Pharmacology, Toxicology and Pharmaceutical Science 9 12%
Chemistry 9 12%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 12 16%
Unknown 17 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2018.
All research outputs
#5,465,612
of 19,503,523 outputs
Outputs from International Journal of Nanomedicine
#543
of 3,403 outputs
Outputs of similar age
#37,775
of 139,294 outputs
Outputs of similar age from International Journal of Nanomedicine
#17
of 78 outputs
Altmetric has tracked 19,503,523 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,403 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 139,294 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.