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A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase

Overview of attention for article published in Neuropsychiatric Disease and Treatment, July 2011
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Mentioned by

twitter
1 tweeter

Citations

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68 Dimensions

Readers on

mendeley
95 Mendeley
Title
A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase
Published in
Neuropsychiatric Disease and Treatment, July 2011
DOI 10.2147/ndt.s17573
Pubmed ID
Authors

Davies, David Christmas, John Potokar

Abstract

This article highlights the evidence linking depression to increased inflammatory drive and explores putative mechanisms for the association by reviewing both preclinical and clinical literature. The enzyme indoleamine 2,3-dioxygenase is induced by proinflammatory cytokines and may form a link between immune functioning and altered neurotransmission, which results in depression. Increased indoleamine 2,3-dioxygenase activity may cause both tryptophan depletion and increased neurotoxic metabolites of the kynurenine pathway, two alterations which have been hypothesized to cause depression. The tryptophan-kynurenine pathway is comprehensively described with a focus on the evidence linking metabolite alterations to depression. The use of immune-activated groups at high risk of depression have been used to explore these hypotheses; we focus on the studies involving chronic hepatitis C patients receiving interferon-alpha, an immune activating cytokine. Findings from this work have led to novel strategies for the future development of antidepressants including inhibition of indoleamine 2,3-dioxygenase, moderating the cytokines which activate it, or addressing other targets in the kynurenine pathway.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 1%
Unknown 94 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 9%
Researcher 4 4%
Student > Postgraduate 2 2%
Student > Bachelor 2 2%
Student > Master 1 1%
Other 2 2%
Unknown 75 79%
Readers by discipline Count As %
Medicine and Dentistry 5 5%
Neuroscience 4 4%
Agricultural and Biological Sciences 2 2%
Biochemistry, Genetics and Molecular Biology 2 2%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 3 3%
Unknown 77 81%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2016.
All research outputs
#4,541,662
of 8,492,090 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,140
of 1,628 outputs
Outputs of similar age
#47,659
of 96,184 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#18
of 33 outputs
Altmetric has tracked 8,492,090 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,628 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,184 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.