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Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response

Overview of attention for article published in Clinical Pharmacology : Advances and Applications, March 2012
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2 tweeters

Citations

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13 Dimensions

Readers on

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19 Mendeley
Title
Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response
Published in
Clinical Pharmacology : Advances and Applications, March 2012
DOI 10.2147/cpaa.s27822
Pubmed ID
Authors

Rolf Kreutz, Perry Nystrom, Yan Jin, Yvonne Kreutz, Miao, Desta, Jeffrey Breall, Li, Chienwei Chiang, Kovacs, Flockhart

Abstract

The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite. Conflicting results have been reported in regard to (1) the association of a common polymorphism of PON1 (Q192R) with reduced rates of coronary stent thrombosis in patients taking clopidogrel and (2) its effects on platelet inhibition in patient populations of European descent.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 5%
Canada 1 5%
Unknown 17 89%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 16%
Researcher 3 16%
Student > Master 3 16%
Student > Ph. D. Student 2 11%
Professor 2 11%
Other 6 32%
Readers by discipline Count As %
Medicine and Dentistry 8 42%
Agricultural and Biological Sciences 5 26%
Nursing and Health Professions 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Computer Science 1 5%
Other 1 5%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2012.
All research outputs
#2,971,887
of 4,506,762 outputs
Outputs from Clinical Pharmacology : Advances and Applications
#51
of 69 outputs
Outputs of similar age
#46,430
of 75,175 outputs
Outputs of similar age from Clinical Pharmacology : Advances and Applications
#3
of 4 outputs
Altmetric has tracked 4,506,762 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 69 research outputs from this source. They receive a mean Attention Score of 1.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,175 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.