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The role of cholesterol-sphingomyelin membrane nanodomains in the stability of intercellular membrane nanotubes

Overview of attention for article published in International Journal of Nanomedicine, April 2012
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Mentioned by

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1 tweeter

Citations

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58 Mendeley
Title
The role of cholesterol-sphingomyelin membrane nanodomains in the stability of intercellular membrane nanotubes
Published in
International Journal of Nanomedicine, April 2012
DOI 10.2147/ijn.s28723
Pubmed ID
Authors

Doron Kabaso

Abstract

Intercellular membrane nanotubes (ICNs) are highly curved tubular structures that connect neighboring cells. The stability of these structures depends on the inner cytoskeleton and the cell membrane composition. Yet, due to the difficulty in the extraction of ICNs, the cell membrane composition remains elusive. In the present study, a raft marker, ostreolysin, revealed the enrichment of cholesterol-sphingomyelin membrane nanodomains along ICNs in a T24 (malignant) urothelial cancer cell line. Cholesterol depletion, due to the addition of methyl-β-cyclodextrin, caused the dispersion of cholesterol-sphingomyelin membrane nanodomains and the retraction of ICNs. The depletion of cholesterol also led to cytoskeleton reorganization and to formation of actin stress fibers. Live cell imaging data revealed the possible functional coupling between the change from polygonal to spherical shape, cell separation, and the disconnection of ICNs. The ICN was modeled as an axisymmetric tubular structure, enabling us to investigate the effects of cholesterol content on the ICN curvature. The removal of cholesterol was predicted to reduce the positive spontaneous curvature of the remaining membrane components, increasing their curvature mismatch with the tube curvature. The mechanisms by which the increased curvature mismatch could contribute to the disconnection of ICNs are discussed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Austria 1 2%
Unknown 56 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 33%
Researcher 9 16%
Student > Master 8 14%
Student > Bachelor 4 7%
Student > Doctoral Student 3 5%
Other 9 16%
Unknown 6 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 29%
Biochemistry, Genetics and Molecular Biology 15 26%
Chemistry 5 9%
Medicine and Dentistry 4 7%
Computer Science 1 2%
Other 6 10%
Unknown 10 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2012.
All research outputs
#9,957,201
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#1,919
of 2,456 outputs
Outputs of similar age
#85,890
of 120,428 outputs
Outputs of similar age from International Journal of Nanomedicine
#43
of 78 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,428 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.