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Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α

Overview of attention for article published in International Journal of Nanomedicine, July 2012
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Citations

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Title
Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α
Published in
International Journal of Nanomedicine, July 2012
DOI 10.2147/ijn.s32592
Pubmed ID
Authors

Nobutaka Hanagata, Manoharan, Qingmin Ji, Yamazaki, Shanmugavel, Chen, Ganesan, Hill, Ariga

Abstract

Class B CpG oligodeoxynucleotides primarily interact with Toll-like receptor 9 (TLR9) in B cells and enhance the immune system through induction of various interleukins including interleukin-6 in these immune cells. Although free class B CpG oligodeoxynucleotides do not induce interferon (IFN)-α production, CpG oligodeoxynucleotide molecules have been reported to induce IFN-α when loaded onto nanoparticles. Here, we investigated the in vitro induction of IFN-α by a nanocarrier delivery system for class B CpG oligodeoxynucleotide molecules.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 8%
Spain 1 4%
United States 1 4%
Unknown 21 84%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 36%
Researcher 6 24%
Professor > Associate Professor 3 12%
Student > Doctoral Student 2 8%
Student > Master 1 4%
Other 2 8%
Unknown 2 8%
Readers by discipline Count As %
Materials Science 6 24%
Agricultural and Biological Sciences 5 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Biochemistry, Genetics and Molecular Biology 2 8%
Chemistry 2 8%
Other 6 24%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2012.
All research outputs
#3,542,529
of 4,507,072 outputs
Outputs from International Journal of Nanomedicine
#937
of 1,146 outputs
Outputs of similar age
#58,722
of 75,176 outputs
Outputs of similar age from International Journal of Nanomedicine
#37
of 61 outputs
Altmetric has tracked 4,507,072 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 1.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,176 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.