Title |
Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α
|
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Published in |
International Journal of Nanomedicine, July 2012
|
DOI | 10.2147/ijn.s32592 |
Pubmed ID | |
Authors |
Yuvaraj Manoharan, Qingmin Ji, Tomohiko Yamazaki, Shanmugavel Chinnathambi, Song Chen, Singaravelu Ganesan, Jonathan P Hill, Katsuhiko Ariga, Nobutaka Hanagata |
Abstract |
Class B CpG oligodeoxynucleotides primarily interact with Toll-like receptor 9 (TLR9) in B cells and enhance the immune system through induction of various interleukins including interleukin-6 in these immune cells. Although free class B CpG oligodeoxynucleotides do not induce interferon (IFN)-α production, CpG oligodeoxynucleotide molecules have been reported to induce IFN-α when loaded onto nanoparticles. Here, we investigated the in vitro induction of IFN-α by a nanocarrier delivery system for class B CpG oligodeoxynucleotide molecules. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 7% |
Spain | 1 | 4% |
United States | 1 | 4% |
Unknown | 24 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 32% |
Researcher | 6 | 21% |
Professor > Associate Professor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Professor | 1 | 4% |
Other | 2 | 7% |
Unknown | 5 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Materials Science | 6 | 21% |
Agricultural and Biological Sciences | 5 | 18% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Chemical Engineering | 2 | 7% |
Other | 6 | 21% |
Unknown | 5 | 18% |