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Understanding lupus nephritis: diagnosis, management, and treatment options

Overview of attention for article published in International Journal of Women's Health, June 2012
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Mentioned by

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1 tweeter

Citations

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26 Dimensions

Readers on

mendeley
110 Mendeley
Title
Understanding lupus nephritis: diagnosis, management, and treatment options
Published in
International Journal of Women's Health, June 2012
DOI 10.2147/ijwh.s28034
Pubmed ID
Authors

Chi Chiu Mok

Abstract

Systemic lupus erythematosus (SLE) predominantly affects women in their reproductive years. Renal disease (glomerulonephritis) is one of the most frequent and serious manifestations of SLE. Of the various histological types of lupus glomerulonephritis, diffuse proliferative nephritis carries the worst prognosis. Combined with high-dose prednisone, mycophenolate mofetil (MMF) has emerged as a first-line immunosuppressive treatment, although data regarding the efficacy of MMF on the long-term preservation of renal function are forthcoming. Cyclophosphamide is reserved for more severe forms of lupus nephritis, such as crescentic glomerulonephritis with rapidly deteriorating renal function, patients with significant renal function impairment at presentation, and refractory renal disease. Evidence for the calcineurin inhibitors in the treatment of lupus nephritis is weaker, and it concerns patients who are intolerant or recalcitrant to other agents. While further controlled trials are mandatory, B cell modulation therapies, such as rituximab, belimumab and epratuzumab are confined to refractory disease. Non-immunosuppressive measures, such as angiotensin-converting enzyme inhibitors, vigorous blood pressure control, prevention and treatment of hyperlipidemia and osteoporosis, are equally important.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 3%
Paraguay 1 <1%
Uruguay 1 <1%
Argentina 1 <1%
United States 1 <1%
Unknown 103 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 28 25%
Student > Master 20 18%
Other 10 9%
Researcher 9 8%
Student > Ph. D. Student 8 7%
Other 27 25%
Unknown 8 7%
Readers by discipline Count As %
Medicine and Dentistry 61 55%
Pharmacology, Toxicology and Pharmaceutical Science 9 8%
Agricultural and Biological Sciences 6 5%
Biochemistry, Genetics and Molecular Biology 6 5%
Immunology and Microbiology 6 5%
Other 8 7%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2012.
All research outputs
#3,564,515
of 4,507,509 outputs
Outputs from International Journal of Women's Health
#207
of 273 outputs
Outputs of similar age
#60,635
of 75,177 outputs
Outputs of similar age from International Journal of Women's Health
#29
of 36 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 273 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,177 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.