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Dove Medical Press

Human normal immunoglobulin in the treatment of primary immunodeficiency diseases

Overview of attention for article published in Therapeutics and Clinical Risk Management, April 2012
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2 X users

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37 Mendeley
Title
Human normal immunoglobulin in the treatment of primary immunodeficiency diseases
Published in
Therapeutics and Clinical Risk Management, April 2012
DOI 10.2147/tcrm.s22599
Pubmed ID
Authors

Philip Wood

Abstract

The primary antibody deficiency syndromes are a rare group of disorders that can present at any age, and for which delay in diagnosis remains common. Replacement therapy with immunoglobulin in primary antibody deficiencies increases life expectancy and reduces the frequency and severity of infection. Higher doses of immunoglobulin are associated with reduced frequency of infection. Late diagnosis and delayed institution of immunoglobulin replacement therapy results in increased morbidity with a wide variety of organ-specific complications and increased mortality. Risks of immunoglobulin therapy are minimized by modern manufacturing processes, although patients can experience both immediate and delayed adverse reactions, and concerns remain over the transmission of prions in plasma. Immunoglobulin therapy leads to improvements in overall quality of life, and many of the improvements relate to reduced infection rates and fear of future infections, strongly suggesting that the immunoglobulin therapy itself is the major factor in this improvement. There are limited data on the economic benefits of immunoglobulin therapy, with the fluctuating costs of immunoglobulins making comparison between different studies difficult. However, estimates suggest that early intervention with immunoglobulin replacement compares favorably with prolonged therapy for other more common chronic diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 16%
Student > Bachelor 5 14%
Student > Ph. D. Student 4 11%
Other 3 8%
Student > Doctoral Student 2 5%
Other 7 19%
Unknown 10 27%
Readers by discipline Count As %
Medicine and Dentistry 16 43%
Biochemistry, Genetics and Molecular Biology 4 11%
Agricultural and Biological Sciences 2 5%
Psychology 2 5%
Immunology and Microbiology 1 3%
Other 2 5%
Unknown 10 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2012.
All research outputs
#17,438,425
of 25,584,565 outputs
Outputs from Therapeutics and Clinical Risk Management
#906
of 1,308 outputs
Outputs of similar age
#113,137
of 173,277 outputs
Outputs of similar age from Therapeutics and Clinical Risk Management
#4
of 6 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,308 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,277 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.