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Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs

Overview of attention for article published in International Journal of Nanomedicine, June 2012
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter

Citations

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38 Dimensions

Readers on

mendeley
43 Mendeley
Title
Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs
Published in
International Journal of Nanomedicine, June 2012
DOI 10.2147/ijn.s30500
Pubmed ID
Authors

Ezharul Hoque Chowdhury, Li, Chu, Kunnath

Abstract

Multidrug resistance, a major impediment to successful cancer chemotherapy, is the result of overexpression of ATP-binding cassette (ABC) transporters extruding internalized drugs. Silencing of ABC transporter gene expression with small interfering RNA (siRNA) could be an attractive approach to overcome multidrug resistance of cancer, although delivery of siRNA remains a major hurdle to fully exploit the potential of siRNA-based therapeutics. Recently, we have developed pH-sensitive carbonate apatite nanoparticles to efficiently carry and transport siRNA across the cell membrane, enabling knockdown of the cyclin B1 gene and consequential induction of apoptosis in synergy with anti-cancer drugs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
India 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 37%
Student > Master 9 21%
Student > Bachelor 4 9%
Student > Doctoral Student 3 7%
Researcher 3 7%
Other 8 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 40%
Agricultural and Biological Sciences 13 30%
Medicine and Dentistry 5 12%
Unspecified 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2012.
All research outputs
#9,957,204
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#1,921
of 2,456 outputs
Outputs of similar age
#85,890
of 120,427 outputs
Outputs of similar age from International Journal of Nanomedicine
#43
of 77 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,427 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.