Title |
Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes
|
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Published in |
International Journal of Nanomedicine, May 2012
|
DOI | 10.2147/ijn.s30617 |
Pubmed ID | |
Authors |
Daniela Frascione, Clemens Diwoky, Gunter Almer, Peter Opriessnig, Caroline Vonach, Kerstin Gradauer, Gerd Leitinger, Harald Mangge, Rudolf Stollberger, Ruth Prassl |
Abstract |
Magnetic liposomes (MLs) are phospholipid vesicles that encapsulate magnetic and/or paramagnetic nanoparticles. They are applied as contrast agents for magnetic resonance imaging (MRI). MLs have an advantage over free magnetic nanocores, in that various functional groups can be attached to the surface of liposomes for ligand-specific targeting. We have synthesized PEG-coated sterically-stabilized magnetic liposomes (sMLs) containing ultrasmall superparamagnetic iron oxides (USPIOs) with the aim of generating stable liposomal carriers equipped with a high payload of USPIOs for enhanced MRI contrast. |
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Mendeley readers
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